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A Multi-omic Association Study of Trimethylamine N-Oxide [PDF]

Cell Reports, 2018
Trimethylamine N-oxide (TMAO) is a circulating metabolite that has been implicated in the development of atherosclerosis and cardiovascular disease (CVD). In this paper, we identify blood markers, metabolites, proteins, gut microbiota patterns, and diets that are significantly associated with levels of plasma TMAO.
Ohad Manor, Matthew P Conomos, Andrew T Magis   +2 more
exaly   +3 more sources

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Trimethylamine N-Oxide (TMAO) as a Biomarker

2022
The interaction between diet, microbiome, and noncommunicable disease onset is gaining growing attention. The trimethylamine N-oxide (TMAO) is a gut microbiota derivative that has been suggested as a potential regulator of human health, especially (but not exclusively) for its association with cardiovascular diseases. It derives from the trimethylamine
Gabbianelli, Rosita, Bordoni, Laura
openaire   +3 more sources

The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline

Journal of the American Society of Nephrology
Visual Abstract Key Points In community-based US adults, higher plasma trimethylamine N-oxide levels associated with higher risk of incident CKD and greater rate of kidney function decline.
Meng Wang, W. Tang, Xinmin S. Li, Marcia C. de Oliveira Otto, Yujin Lee, R. Lemaitre, A. Fretts, Ina Nemet, N. Sotoodehnia, C. Sitlani, Matthew J. Budoff, J. DiDonato, Zeneng Wang, N. Bansal, M. Shlipak, B. Psaty, D. Siscovick, M. Sarnak, D. Mozaffarian, Stanley L. Hazen   +19 more
semanticscholar   +1 more source

Microbial Dimethylsulfoxide and Trimethylamine-N-Oxide Respiration

2005
Over the last two decades, the biochemistry and genetics of dimethylsulfoxide (DMSO) and trimethylamine-N-oxide (TMAO) respiration has been characterised, particularly in Escherichia coli marine bacteria of the genus Shewanella and the purple phototrophic bacteria, Rhodobacter sphaeroides and R. capsulatus.
McCrindle, S. L., Kappler, U., McEwan, A. G.   +2 more
openaire   +3 more sources

A comparative study of trimethylamine-N-oxide biosynthesis

Biochimica et Biophysica Acta, 1963
A broad spectrum of species of plants and animals have been examined for their ability to convert trimethylamine to its N-oxide. Of the animal species studied, and under the conditions used in this investigation, trimethylamine-N-oxide synthesis from trimethylamine seems generally to be restricted to the vertebrates.
J R, BAKER, A, STRUEMPLER, S, CHAYKIN
openaire   +2 more sources

Trimethylamine N-Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations

Circulation: Heart Failure
BACKGROUND: Growing evidence indicates that trimethylamine N-oxide, a gut microbial metabolite of dietary choline and carnitine, promotes both cardiovascular disease and chronic kidney disease risk.
W. Tang, R. Lemaitre, P. Jensen, Meng Wang, Zeneng Wang, Xinmin S. Li, Ina Nemet, Yujin Lee, Heidi T M Lai, Marcia C. de Oliveira Otto, A. Fretts, N. Sotoodehnia, J. DiDonato, Fredrik Bäckhed, B. Psaty, D. Siscovick, Matthew J. Budoff, D. Mozaffarian, Stanley L. Hazen   +18 more
semanticscholar   +1 more source

Trimethylamine-N-oxide

Current Opinion in Lipidology, 2016
This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson, Cheynne, McLean, Richard B, Kim   +2 more
openaire   +2 more sources

Trimethylamine N-oxide impairs perfusion recovery after hindlimb ischemia

Biochemical and Biophysical Research Communications, 2020
The circulating level of trimethylamine N-oxide (TMAO) has been reported to be associated with the prognosis of of peripheral arterial disease (PAD) patients. However, the effects of TMAO on neovascularization and perfusion recovery after PAD are not known.Unilateral hindlimb ischemia was generated in mice as experimental PAD model, TMAO or 3,3 ...
Lingdan, Chen, Yinkang, Jin, Neng, Wang, Mingjie, Yuan, Tao, Lin, Wenju, Lu, Tao, Wang   +6 more
openaire   +2 more sources

การตรวจ trimethylamine n-oxide (TMAO) ในซีรัมเพื่อทำนายภาวะหลอดเลือดแข็งตัวในผู้ป่วยโรคไตเรื้อรัง

2023
ความเป็นมา: การเพิ่มขึ้นของสาร trimethylamine N-oxide (TMAO) ซึ่งเป็นสารพิษที่มาจากแบคทีเรียในลำไส้ของผู้ป่วยโรคไตเรื้อรัง (chronic kidney disease; CKD) อาจช่วยเพิ่มการผลิต TMAO reductase ซึ่งเป็นเอนไซม์ของแบคทีเรียในลำไส้และมีการแทรกผ่านไปยังกระแสเลือดอันเนื่องมาจากข้อบกพร่องในการซึมผ่านของลำไส้ (gut leakage) และอาจนำมาใช้เป็นตัวบ่งชี้ภาวะหลอดเลือดแข ...
openaire   +1 more source

Ultraviolet absorption spectra of trimethylamine N-oxide

Journal of Molecular Spectroscopy, 1966
Abstract Ultraviolet absorption spectra of trimethylamine N-oxide were recorded in several solvents, a band being found around 198 mμ with ϵ ≈ 2350 in acetonitrile solvent. However, in ethyl alcohol and in water this band undergoes a large blue shift and decreases in intensity.
Tanekazu Kubota, Masumi Yamakawa, Itaru Tanaka   +2 more
openaire   +1 more source