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Trimethylamine N-Oxide (TMAO) as a Biomarker
2022The interaction between diet, microbiome, and noncommunicable disease onset is gaining growing attention. The trimethylamine N-oxide (TMAO) is a gut microbiota derivative that has been suggested as a potential regulator of human health, especially (but not exclusively) for its association with cardiovascular diseases. It derives from the trimethylamine
Gabbianelli, Rosita, Bordoni, Laura
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การตรวจ trimethylamine n-oxide (TMAO) ในซีรัมเพื่อทำนายภาวะหลอดเลือดแข็งตัวในผู้ป่วยโรคไตเรื้อรัง
2023ความเป็นมา: การเพิ่มขึ้นของสาร trimethylamine N-oxide (TMAO) ซึ่งเป็นสารพิษที่มาจากแบคทีเรียในลำไส้ของผู้ป่วยโรคไตเรื้อรัง (chronic kidney disease; CKD) อาจช่วยเพิ่มการผลิต TMAO reductase ซึ่งเป็นเอนไซม์ของแบคทีเรียในลำไส้และมีการแทรกผ่านไปยังกระแสเลือดอันเนื่องมาจากข้อบกพร่องในการซึมผ่านของลำไส้ (gut leakage) และอาจนำมาใช้เป็นตัวบ่งชี้ภาวะหลอดเลือดแข ...
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Current Opinion in Lipidology, 2016
This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson +2 more
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This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson +2 more
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Trimethylamine N-oxide impairs perfusion recovery after hindlimb ischemia
Biochemical and Biophysical Research Communications, 2020The circulating level of trimethylamine N-oxide (TMAO) has been reported to be associated with the prognosis of of peripheral arterial disease (PAD) patients. However, the effects of TMAO on neovascularization and perfusion recovery after PAD are not known.Unilateral hindlimb ischemia was generated in mice as experimental PAD model, TMAO or 3,3 ...
Lingdan, Chen +6 more
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Ultraviolet absorption spectra of trimethylamine N-oxide
Journal of Molecular Spectroscopy, 1966Abstract Ultraviolet absorption spectra of trimethylamine N-oxide were recorded in several solvents, a band being found around 198 mμ with ϵ ≈ 2350 in acetonitrile solvent. However, in ethyl alcohol and in water this band undergoes a large blue shift and decreases in intensity.
Tanekazu Kubota +2 more
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Trimethylamine N-oxidation in Turkish women with bacterial vaginosis
Pharmacogenetics, 1996Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of child-bearing age. A common symptom of this condition is a fishy-smelling vaginal discharge. Trimethylamine (TMA) is the substance which is primarily responsible for this distinctive odour.
Green, RL +5 more
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Gut microbial metabolite trimethylamine N-oxide induces aortic dissection
Journal of Molecular and Cellular CardiologyAortic dissection (AD) is the most catastrophic vascular disease with a high mortality rate. Trimethylamine N-oxide (TMAO), a gut microbial metabolite, has been implicated in the pathogenesis of cardiovascular diseases. However, the role of TMAO in AD and the underlying mechanisms remain unclear.
Shan, Huang +8 more
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