Results 141 to 150 of about 11,599 (170)
Some of the next articles are maybe not open access.
The Metabolic Fate of Isotopically Labeled Trimethylamine-N-Oxide (TMAO) in Humans
Journal of Nutritional Biochemistry, 2017Trimethylamine-N-oxide (TMAO) is associated with chronic disease risk. However, little is known about the metabolic fate of dietary TMAO. This study sought to quantitatively elucidate the metabolic fate of orally consumed TMAO in humans. As part of a crossover feeding study, healthy young men (n=40) consumed 50-mg deuterium-labeled methyl d9-TMAO (d9 ...
Julia H King +2 more
exaly +3 more sources
Trimethylamine N-oxide (TMAO): a new attractive target to decrease cardiovascular risk
Postgraduate Medical Journal, 2021AbstractCardiovascular disease (CVD) is one of the greatest disease burdens and takes the lives of many each year. There are many risk factors both modifiable and non-modifiable which contribute to the onset and progression of the disease. Trimethylamine N-oxide (TMAO) in recent years has been found to have a correlation with CVD onset.
Ione Swanepoel +6 more
openaire +4 more sources
Trimethylamine N-Oxide (TMAO): a Unique Counteracting Osmolyte?
Paracelsus Proceedings of Experimental Medicine, 2023Cells of many organisms facing osmotic shrinkage or swelling undergo homeostatic volume regulation using osmolytes—inorganic ions (Na+, K+, Cl-) in transient disturbances, but special organic osmolytes in long-term disturbances. Neutral amino acids, methylamines and polyols are key examples.
openaire +1 more source
การตรวจ trimethylamine n-oxide (TMAO) ในซีรัมเพื่อทำนายภาวะหลอดเลือดแข็งตัวในผู้ป่วยโรคไตเรื้อรัง
2023ความเป็นมา: การเพิ่มขึ้นของสาร trimethylamine N-oxide (TMAO) ซึ่งเป็นสารพิษที่มาจากแบคทีเรียในลำไส้ของผู้ป่วยโรคไตเรื้อรัง (chronic kidney disease; CKD) อาจช่วยเพิ่มการผลิต TMAO reductase ซึ่งเป็นเอนไซม์ของแบคทีเรียในลำไส้และมีการแทรกผ่านไปยังกระแสเลือดอันเนื่องมาจากข้อบกพร่องในการซึมผ่านของลำไส้ (gut leakage) และอาจนำมาใช้เป็นตัวบ่งชี้ภาวะหลอดเลือดแข ...
openaire +1 more source
Trimethylamine-N-Oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome [PDF]
Nutrients, 2018 There is a mechanistic link between the gut-derived metabolite trimethylamine-N-oxide (TMAO) and obesity-related diseases, suggesting that the TMAO pathway may also be linked to the pathogenesis of obesity. The Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction, and the Fatty Liver Index (FLI), a predictor of non ...
Annamaria Colao +2 more
exaly +4 more sources
Complex Formation in Aqueous Trimethylamine-N-oxide (TMAO) Solutions
The Journal of Physical Chemistry B, 2012We study aqueous solutions of the amphiphilic osmolyte trimethylamine-N-oxide (TMAO) using broadband dielectric spectroscopy and femtosecond mid-infrared spectroscopy. Both experiments provide strong evidence for distinctively slower rotation dynamics for water molecules interacting with the hydrophobic part of the TMAO molecules.
Hunger, J. +4 more
openaire +3 more sources
On the Influence of Trimethylamine-N-oxide (TMAO) and Pressure on Hydrophobic Interactions
2022Osmolyte sind kleine organische Moleküle, welche das Faltungsgleichgewicht von Proteinen und die Bildung biomolekularer Kondensate durch liquid-liquid phase separation (LLPS) beeinflussen. Dadurch können sie Zellen von extrazellulärem Stress durch andere Moleküle oder externen Variablen wie Druck, Temperatur und pH schützen und erlauben das Gedeihen ...
openaire +1 more source
Gut, 2019
We read with great interest the paper by Wu et al 1 reporting on the development of a carnitine challenge test to facilitate the identification of trimethylamine N-oxide (TMAO)-producer phenotype and host-diet-gut dysbiosis. Such a test assumes that, according to a partial reading of the literature, TMAO plays a key role in cardiovascular disease (CVD).
Arduino Arduini +2 more
openaire +3 more sources
We read with great interest the paper by Wu et al 1 reporting on the development of a carnitine challenge test to facilitate the identification of trimethylamine N-oxide (TMAO)-producer phenotype and host-diet-gut dysbiosis. Such a test assumes that, according to a partial reading of the literature, TMAO plays a key role in cardiovascular disease (CVD).
Arduino Arduini +2 more
openaire +3 more sources
Serum Trimethylamine N‐Oxide (TMAO), Diet, and Colorectal Cancer Risk
The FASEB Journal, 2016Objective Choline and carnitine are two compounds that are found in human diets and can be metabolized to trimethylamine (TMA) and, ultimately, to Trimethylamine N‐Oxide (TMAO) by the gut microbiota. There is evidence that individuals with higher serum TMAO concentrations may have subclinical inflammation and ...
Kristin A Guertin +5 more
openaire +1 more source
The Role of Trimethylamine N-oxide(TMAO) in Different Cardiovascular Phenotypes
2022Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Increased trimethylamine N-oxide (TMAO) levels have been shown to associate with cardiovascular disease and predict outcomes in the presence of multiple CVD phenotypes. The present review focuses on TMAO’s involvement in the main pathogenetic pathways causing or aggravating the ...
Lieponytė, Austėja +2 more
openaire +1 more source