Results 1 to 10 of about 10,278 (188)

Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography–Mass Spectrometry [PDF]

Molecules, 2020
Trimethylamine (TMA) is a gut microbial metabolite—rendered by the enzymatic cleavage of nutrients containing a TMA moiety in their chemical structure.
Xun Jia, Lucas J. Osborn, Zeneng Wang
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A mixture of postbiotics/tyndallized probiotics reduces trimethylamine (TMA) in trimethylaminuria models: Evidence from in vitro and in vivo studies [PDF]

Frontiers in Pharmacology
IntroductionTrimethylaminuria (TMAU), also known as “fish-odor syndrome,” is a rare metabolic disorder characterized by a body malodor that smells like a decaying fish. This syndrome is caused by a FMO3 liver enzyme malfunction, leading to trimethylamine
Giuseppe Giannini, Sara Soldi, Marina Elli, Valeria Sagheddu, Andrea Castagnetti, Elisa Viciani, Laura Salvini, Gianfranco Battistuzzi, Ferdinando Maria Milazzo, Simona Alibrandi, Simona Alibrandi, Antonina Sidoti   +11 more
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Monooxygenase-dehydrogenase cascade for sustained enzymatic remediation of TMA in salmon protein hydrolysates [PDF]

Applied and Environmental Microbiology
Fish protein hydrolysates hold great promise as nutraceuticals, yet their application as food ingredients or nutraceuticals is currently limited by their fish-like odor. This odor is mainly due to the presence of trimethylamine (TMA), a volatile biogenic
Rasmus Ree, Øivind Larsen, Sushil Gaykawad, Sreerekha S. Ramanand, Antonio García-Moyano, Irina Elena Chiriac, Pål Puntervoll, Gro Elin Kjæreng Bjerga   +7 more
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Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5 [PDF]

eLife
Elevated levels of the gut microbe-derived metabolite trimethylamine N-oxide (TMAO) are associated with cardiometabolic disease risk. However, the mechanism(s) linking TMAO production to human disease are incompletely understood.
Kala K Mahen, William J Massey, Danny Orabi, Amanda L Brown, Thomas C Jaramillo, Amy Burrows, Anthony J Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes, Venkateshwari Varadharajan, Lucas J Osborn, Xiayan Ye, Dante M Yarbrough, Treg Grubb, Natalie Zajczenko, Rachel Hohe, Rakhee Banerjee, Pranavi Linga, Dev Laungani, Adeline M Hajjar, Naseer Sangwan, Mohammed Dwidar, Jennifer A Buffa, Garth R Swanson, Zeneng Wang, Jonathan Mark Brown   +26 more
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Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism [PDF]

mBio
Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host’s impaired ability to oxidize TMA to trimethylamine-N-oxide (TMAO) results in trimethylaminuria (TMAU), while elevated ...
Amelia Y. M. Woo, Walter J. Sandoval-Espinola, Maud Bollenbach, Alison Wong, Mariko Sakanaka-Yokoyama, Qijun Zhang, Vincent Nieto, Federico E. Rey, Emily P. Balskus   +8 more
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A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine [PDF]

MethodsX, 2017
Our method describes the quantification in mouse urine of trimethylamine (TMA), trimethylamine N-oxide (TMAO) and creatinine. The method combines derivatization of TMA, with ethyl bromoacetate, and LC chromatographic separation on an ACE C18 column.
Sunil Veeravalli, Kersti Karu, Ian R. Phillips, Elizabeth A. Shephard   +3 more
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Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Colon Microbiome In Vitro [PDF]

Metabolites
Background/Objectives: Gut microbial metabolism of choline and related quaternary amines to trimethylamine (TMA) is the first step in the production of trimethylamine N-oxide (TMAO), a circulating metabolite that contributes to the development of ...
Anthony M. Buckley, Sarah Zaidan, Michael G. Sweet, Duncan J. Ewin, Juanita G. Ratliff, Aliyah Alkazemi, William Davis Birch, Ashley M. McAmis, Andrew P. Neilson   +8 more
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Exploring the trimethylamine-degrading genes in the human gut microbiome [PDF]

AMB Express
Trimethylamine (TMA), produced by gut microbes, is a precursor to a risk factor for cardiovascular diseases. Currently, TMA-degrading bacteria in the human gut have rarely been studied. This study combined TMA-enriched cultures (from 104 young male stool
Yi-Ran Chen, Li-Dan Chen, Lin-Jie Zheng
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Trimethylamine-N-oxide formation, the bacterial taxa involved and intervention strategies to reduce its concentration in the human body [PDF]

Annals of Medicine
Introduction This study reviews the different steps involved in trimethylamine-N-oxide (TMAO) formation, a gut microbiota (GM)-derived compound that promotes cardiovascular and chronic kidney disease.
Ylenia Heinrich-Sanchez, Marius Vital
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Effects of Trimethylamine Concentrations in Hatching Eggs on Chick Quality in Dwarf Hens [PDF]

Animals
Microbial contamination of hatching eggs often leads to reduced hatchability and poor chick quality. As trimethylamine (TMA), a metabolite derived from dietary choline, has antimicrobial properties, increasing yolk TMA contents may increase bacterial ...
Xuefeng Shi, Lin Xuan, Jiahui Lai, Caiyun Jiang, Junying Li, Guiyun Xu, Jiangxia Zheng   +6 more
doaj   +2 more sources