Results 81 to 90 of about 10,278 (188)

Molecular Basis of C–N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase [PDF]

, 2018
Deamination of choline catalyzed by the glycyl radical enzyme choline trimethylamine-lyase (CutC) has emerged as an important route for the production of trimethylamine, a microbial metabolite associated with both human disease and biological methane ...
Balskus, Emily P., Bodea, Smaranda, Drennan, Catherine L, Funk, Michael Andrew   +3 more
core   +1 more source

Trimethylamine N‐oxide is elevated in postmenopausal women relative to age‐matched men and premenopausal women among individuals with obesity

Experimental Physiology, Volume 111, Issue 3, Page 798-808, 1 March 2026.
Abstract Trimethylamine N‐oxide (TMAO) is linked to arterial stiffness and atherosclerosis. Cardiovascular disease (CVD) risk increases following menopause in women. Whether menopause influences plasma TMAO metabolism to mediate CVD risk is unknown.
Daniel J. Battillo, Steven K. Malin
wiley   +1 more source

Choline diet improves serum lipid parameters and alters egg composition in breeder ducks

Veterinary Medicine and Science, 2022
Background Choline is an important nutrient, playing key roles in numerous metabolic pathways relevant to animal health. Objectives The objective of this study was to evaluate the effect of dietary choline on the lipid parameters, cardiovascular health ...
Jianlou Song, Xuefeng Shi, Xingzheng Li, Jiangxia Zheng   +3 more
doaj   +1 more source

A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites

Physiological Reports, Volume 14, Issue 5, March 2026.
Vitamin D status in our pilot study was associated with higher levels of certain amino acids and hexanoic acid in breast milk and metabolites in infant stool samples. Abstract Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status.
Alyssa S. Gutierrez, Katherine E. Chetta, Santosh Thapa, Sigmund J. Haidacher, Kathleen M. Hoch, John E. Baatz, Anthony M. Haag, Numan Oezguen, Thomas D. Horvath, Carol L. Wagner, Melinda A. Engevik   +10 more
wiley   +1 more source

The food-derived metabolite trimethylamine and trimethylamine-N-oxide promote colorectal cancer progression via SREBF1

Ecotoxicology and Environmental Safety
Colorectal cancer (CRC) is characterised by microbial dysbiosis. Trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) are gut microbiota-derived metabolites produced from dietary precursors that are implicated in CRC progression.
Yang Yan, Jiaxuan Li, Hejia Xu, Chen Yang, Guifang Li, Yanyan Feng, Qian Wang, Li Li, Rendi Wu, Hairong Sun, Ting Zhang, Fang Wang, Yong Mao   +12 more
doaj   +1 more source

Detailed experimental iced-storage characteristics of Barents Sea cod (Gadus morhua) [PDF]

, 1998
Im August 1997 wurde an Bord des FFS „Walther Herwig“ ein Eislagerversuch mit Kabeljau aus der Barebtssee durchgeführt. Die Fische wurden in täglichem Abstand auf ihre chemischen, physikalischen, sensorischen und mikrobiologischen Eigenschaften hin ...
Oehlenschläger, Jörg
core  

Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease [PDF]

, 2016
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. However, on a daily basis we are exposed to one of the most abundant substrates of the enzyme, trimethylamine, which is released ...
Fennema, D, Phillips, IR, Shephard, EA
core   +1 more source

Derivatization to reduce background interferences for simultaneous quantitation of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) using liquid chromatography with tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis
Trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) play a crucial role in many biochemical processes within diverse organisms including animals, plants, fungi and bacteria. Studies have linked these metabolites with cardiovascular and kidney diseases; however, emerging evidence demonstrates their protective properties.
Valdivia-Garcia, Maria A., Bi, Yang, Abaakil, Kaoutar, V Li, Jia   +3 more
openaire   +3 more sources

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Structural basis of a microbial trimethylamine transporter

mBio
Trimethylamine (TMA), a simple trace biogenic amine resulting from the decomposition of proteins and other macromolecules, is ubiquitous in nature. It is found in the human gut as well as in various terrestrial and marine ecosystems.
Chao Gao, Hai-Tao Ding, Kang Li, Hai-Yan Cao, Ning Wang, Zeng-Tian Gu, Qing Wang, Mei-Ling Sun, Xiu-Lan Chen, Yin Chen, Yu-Zhong Zhang, Hui-Hui Fu, Chun-Yang Li   +12 more
doaj   +1 more source