Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster [PDF]
Frontiers in Synaptic Neuroscience, 2023 IntroductionNumerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxygen free radicals.
Aelfwin Stone +6 more
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Virtual Screening of Benzimidazole Derivatives as Potential Triose Phosphate Isomerase Inhibitors with Biological Activity against Leishmania mexicana [PDF]
Pharmaceuticals, 2023 Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), a “Neglected disease”, for which the search for new drugs is a priority.
Lenci K. Vázquez-Jiménez +9 more
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Triose Phosphate Isomerase Structure-Based Virtual Screening and In Vitro Biological Activity of Natural Products as Leishmania mexicana Inhibitors [PDF]
Pharmaceutics, 2023 Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine is available to prevent the disease, and available medical treatments cause serious side effects.
Luis D. González-Morales +10 more
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Leishmania donovani triose phosphate isomerase: a potential vaccine target against visceral leishmaniasis. [PDF]
PLoS ONE, 2012 Visceral leishmaniasis (VL) is one of the most important parasitic diseases with approximately 350 million people at risk. Due to the non availability of an ideal drug, development of a safe, effective, and affordable vaccine could be a solution for ...
Pramod K Kushawaha +6 more
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The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. [PDF]
PLoS Pathogens, 2014 Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects.
James P Hewitson +8 more
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Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency [PDF]
SLAS DiscoveryTriosephosphate Isomerase deficiency (TPI-Df) is a devastating untreatable childhood metabolic disease resulting in anemia, severe locomotor impairment, and premature death.
Laura L. Vollmer +15 more
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Unusually long life in a child with Triose Phosphate Isomerase Deficiency
Pediatric Hematology Oncology Journal, 2022 Susan Salari +3 more
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Differential heat-response characteristics of two plastid isoforms of triose phosphate isomerase in tomato. [PDF]
Plant Biotechnol J, 2023 Chen C, Zhang M, Ma X, Meng Q, Zhuang K.
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Virtual Screening of FDA-Approved Drugs against Triose Phosphate Isomerase from Entamoeba histolytica and Giardia lamblia Identifies Inhibitors of Their Trophozoite Growth Phase. [PDF]
Int J Mol Sci, 2021 Juárez-Saldivar A +8 more
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Density Functional Theory Calculations and Molecular Docking Analyses of Flavonoids for Their Possible Application against the Acetylcholinesterase and Triose-Phosphate Isomerase Proteins of Rhipicephalus microplus. [PDF]
Molecules, 2023 Malak N +7 more
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