Results 11 to 20 of about 6,160 (172)
Natural and Synthetic Metabolic Architectures. [PDF]
ChembiochemMetabolism yields function through architecture, not through isolated parts. This Perspective article discusses how design can move from components to connectivity and then to architectural regimes that account for space, time, and routing. The framework links understanding to engineering and helps explain why microbial engineering meets challenges ...
Nikel PI.
europepmc +2 more sources
The active centre of triose phosphate isomerase [PDF]
Biochemical Journal, 1966 The molecular weight and amino acid composition of triose phosphate isomerase have been determined. The molecular weight (43000) is lower and the molecular activity (500000) higher than those of most other glycolytic enzymes. Reaction with iodoacetate (studied with radioactive reagent) takes place in two phases: in the first phase, at pH6.3, cysteine ...
P M, Burton, S G, Waley
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In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Human African trypanosomiasis (HAT), a parasitic protozoal disease, is caused primarily by two subspecies of Trypanosoma brucei. HAT is a re-emerging disease and currently threatens millions of people in sub-Saharan Africa.
William N Setzer, Ifedayo V Ogungbe
doaj +1 more source
Molecules, 2020 Fasciola hepatica, the causative agent of fasciolosis, is a global threat to public health, animal welfare, agricultural productivity, and food security.
Clare F. Collett +4 more
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Identification and Characterization of Pituitary Triose‐Phosphate Isomerase [PDF]
European Journal of Biochemistry, 1972 Several pituitary preparations from various species, including two purified follicle‐stimulating hormone preparations, inhibited the D‐glyceraldehyde‐3‐phosphate dehydrogenase reaction. The active factor in those preparations that caused the apparent inhibition has been identified as an enzyme, triose phosphate isomerase.
M M, Greenberg, T T, Yen, J L, Bobbitt
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Studies of triose phosphate isomerase by hydrogen exchange [PDF]
Biochemical Journal, 1974 The3H–H exchange of chicken muscle and rabbit muscle triose phosphate isomerases was studied. Their behaviour was mostly very similar. ‘Exchange-in’ (acquisition of radioactivity when protein was incubated in3H2O) was measured at 37°C and at pH7.5, and the rates of exchange of the native and liganded enzymes were compared.
C A, Browne, S G, Waley
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Triosephosphate isomerase from Fasciola hepatica: high-resolution crystal structure as a drug target. [PDF]
Acta Crystallogr F Struct Biol CommunThe high‐resolution crystal structure of triosephosphate isomerase from F. hepatica was solved at 1.51 Å resolution in its monoclinic form, revealing details of the dimer interface critical for enzyme function. Molecular docking with the fasciolocide triclabendazole suggests selective binding near nonconserved residues, highlighting this enzyme as a ...
Kontellas G +5 more
europepmc +2 more sources
pH-dependence of the triose phosphate isomerase reaction [PDF]
Biochemical Journal, 1972 The pH-dependences of the kinetic parameters kcat. and Km for the triose phosphate isomerase reaction were determined in each direction. Apparent pKa values of 6.0 and 9.0 are observed in the dependences of kcat./Km. The pH-dependences of kcat. are sigmoid, with apparent pKa values of about 6.0.
B, Plaut, J R, Knowles
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Bulgarian Journal of Veterinary Medicine, 2022 To determine the genotypes and zoonotic potentials of G. duodenalis isolates from different popula-tions of domestic dogs in Japan, a total of 114 Giardia positive samples were examined using multi-locus genotyping analysis at the 3 loci of glutamate ...
N. Itoh +3 more
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Prevalence and molecular characterization of Giardia intestinalis isolated from children and calves in Babylon province, Iraq [PDF]
Veterinary World, 2023 Background and Aim: Giardia intestinalis is one of the most prevalent intestinal parasites in humans and animals, and children in close contact with livestock are particularly at risk of infection.
Haider H. Alseady +2 more
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