Results 31 to 40 of about 6,160 (172)

Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes.

PLoS ONE, 2006
Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder caused by various mutations in the gene encoding the key glycolytic enzyme TPI.
Markus Ralser, Gino Heeren, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch   +4 more
doaj   +1 more source

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Neurobiology of Disease, 2013
Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study
Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino   +5 more
doaj   +1 more source

Epitope-specific immunity against Staphylococcus aureus coproporphyrinogen III oxidase

npj Vaccines, 2021
Staphylococcus aureus represents a serious infectious threat to global public health and a vaccine against S. aureus represents an unmet medical need. We here characterise two S. aureus vaccine candidates, coproporphyrinogen III oxidase (CgoX) and triose
Alexander Klimka, Sonja Mertins, Anne Kristin Nicolai, Liza Marie Rummler, Paul G. Higgins, Saskia Diana Günther, Bettina Tosetti, Oleg Krut, Martin Krönke   +8 more
doaj   +1 more source

Disequilibrium in the triose phosphate isomerase system in rat liver [PDF]

Biochemical Journal, 1969
1. The equilibrium constant at 38° and I 0·25 of the triose phosphate isomerase reaction was found to be 22·0 and that of the aldolase reaction, 0·99×10−4m. The [dihydroxyacetone phosphate]/[glyceraldehyde phosphate] ratio was found to be 9·3 in rat liver. The causes of the apparent deviation of the triose phosphate isomerase system from equilibrium in
R L, Veech, L, Raijman, K, Dalziel, H A, Krebs   +3 more
openaire   +2 more sources

Giardia duodenalis genetic assemblages and hosts

Parasite, 2016
Techniques for sub-classifying morphologically identical Giardia duodenalis trophozoites have included comparisons of the electrophoretic mobility of enzymes and of chromosomes, and sequencing of genes encoding β-giardin, triose phosphate isomerase, the ...
Heyworth Martin F.
doaj   +1 more source

First description of Giardia duodenalis in buffalo calves (Bubalus bubalis) in southwest region of São Paulo State, Brazil

Food and Waterborne Parasitology, 2019
We performed molecular characterization of Giardia duodenalis in buffalo calves from the Southwest region of São Paulo State, Brazil. A total of 183 fecal samples of Murrah breed buffaloes up to six months of age were collected. We examined these samples
Monally Conceição Costa de Aquino, Tatiani Vitor Harvey, Sandra Valéria Inácio, Walter Bertequini Nagata, Elis Domingos Ferrari, Bruno César Miranda Oliveira, George Rego Albuquerque, Giovanni Widmer, Marcelo Vasconcelos Meireles, Katia Denise Saraiva Bresciani   +9 more
doaj   +1 more source

Multiplex PCR for identification of two butterfly sister species: Eurema mandarina and Eurema hecabe

BMC Research Notes, 2020
Objective In insects, closely related species are often difficult or impossible to distinguish solely by morphological traits. Mitochondrial DNA (mtDNA) markers are often useful and reliable for distinguishing closely related species.
Mai N. Miyata, Daisuke Kageyama, Masashi Nomura   +2 more
doaj   +1 more source

Immunogenicity and Protective Efficacy of T-Cell Epitopes Derived From Potential Th1 Stimulatory Proteins of Leishmania (Leishmania) donovani

Frontiers in Immunology, 2019
Development of a suitable vaccine against visceral leishmaniasis (VL), a fatal parasitic disease, is considered to be vital for maintaining the success of kala-azar control programs.
Sumit Joshi, Narendra Kumar Yadav, Keerti Rawat, Vikash Kumar, Rafat Ali, Amogh Anant Sahasrabuddhe, Mohammad Imran Siddiqi, Wahajul Haq, Shyam Sundar, Anuradha Dube   +9 more
doaj   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source