Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster [PDF]
Frontiers in Synaptic Neuroscience, 2023 IntroductionNumerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxygen free radicals.
Aelfwin Stone +6 more
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Virtual Screening of Benzimidazole Derivatives as Potential Triose Phosphate Isomerase Inhibitors with Biological Activity against Leishmania mexicana [PDF]
Pharmaceuticals, 2023 Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), a “Neglected disease”, for which the search for new drugs is a priority.
Lenci K. Vázquez-Jiménez +9 more
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Triose Phosphate Isomerase Structure-Based Virtual Screening and In Vitro Biological Activity of Natural Products as Leishmania mexicana Inhibitors [PDF]
Pharmaceutics, 2023 Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine is available to prevent the disease, and available medical treatments cause serious side effects.
Luis D. González-Morales +10 more
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Leishmania donovani triose phosphate isomerase: a potential vaccine target against visceral leishmaniasis. [PDF]
PLoS ONE, 2012 Visceral leishmaniasis (VL) is one of the most important parasitic diseases with approximately 350 million people at risk. Due to the non availability of an ideal drug, development of a safe, effective, and affordable vaccine could be a solution for ...
Pramod K Kushawaha +6 more
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The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. [PDF]
PLoS Pathogens, 2014 Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects.
James P Hewitson +8 more
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Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency [PDF]
SLAS DiscoveryTriosephosphate Isomerase deficiency (TPI-Df) is a devastating untreatable childhood metabolic disease resulting in anemia, severe locomotor impairment, and premature death.
Laura L. Vollmer +15 more
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A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency [PDF]
SLAS Discovery, 2021 Andreas Vogt +2 more
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Perdeuteration, large crystal growth and neutron data collection ofLeishmania mexicanatriose-phosphate isomerase E65Q variant [PDF]
Acta Crystallographica Section F, Structural Biology Communications, 2019 Vinardas Kelpšas +2 more
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Characterization of stress and methylglyoxal inducible triose phosphate isomerase (OscTPI) from rice [PDF]
Plant Signaling and Behavior, 2012 Ananda Mustafiz +2 more
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Molecular dynamics simulations of the interactions between triose phosphate isomerase and sulfonamides [PDF]
PeerJ Physical Chemistry, 2020 Malaria is a disease with debilitating health and negative economic impacts in regions at high risk of infection. Parasitic resistance and side effects of current antimalarial drugs are major setbacks to the successful campaigns that have reduced malaria
Neville Y. Forlemu, Joseph Sloop
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