The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. [PDF]
PLoS Pathogens, 2014 Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects.
James P Hewitson +8 more
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Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster [PDF]
Frontiers in Synaptic Neuroscience, 2023 IntroductionNumerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxygen free radicals.
Aelfwin Stone +6 more
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Virtual Screening of Benzimidazole Derivatives as Potential Triose Phosphate Isomerase Inhibitors with Biological Activity against Leishmania mexicana [PDF]
Pharmaceuticals, 2023 Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), a “Neglected disease”, for which the search for new drugs is a priority.
Lenci K. Vázquez-Jiménez +9 more
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Triose Phosphate Isomerase Structure-Based Virtual Screening and In Vitro Biological Activity of Natural Products as Leishmania mexicana Inhibitors [PDF]
Pharmaceutics, 2023 Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine is available to prevent the disease, and available medical treatments cause serious side effects.
Luis D. González-Morales +10 more
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Leishmania donovani triose phosphate isomerase: a potential vaccine target against visceral leishmaniasis. [PDF]
PLoS ONE, 2012 Visceral leishmaniasis (VL) is one of the most important parasitic diseases with approximately 350 million people at risk. Due to the non availability of an ideal drug, development of a safe, effective, and affordable vaccine could be a solution for ...
Pramod K Kushawaha +6 more
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Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency [PDF]
SLAS DiscoveryTriosephosphate Isomerase deficiency (TPI-Df) is a devastating untreatable childhood metabolic disease resulting in anemia, severe locomotor impairment, and premature death.
Laura L. Vollmer +15 more
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Characterization of Sinorhizobium meliloti triose phosphate isomerase genes. [PDF]
J Bacteriol, 2007 ABSTRACT A Tn 5 mutant strain of Sinorhizobium meliloti with an insertion in tpiA (systematic identifier SMc01023), a putative triose phosphate isomerase (TPI)-encoding gene, was isolated. The tpiA mutant grew more slowly than the wild
Poysti NJ, Oresnik IJ.
europepmc +4 more sources
Molecular dynamics simulations of the interactions between triose phosphate isomerase and sulfonamides [PDF]
PeerJ Physical Chemistry, 2020 Malaria is a disease with debilitating health and negative economic impacts in regions at high risk of infection. Parasitic resistance and side effects of current antimalarial drugs are major setbacks to the successful campaigns that have reduced malaria
Neville Y. Forlemu, Joseph Sloop
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Molecules, 2020 Fasciola hepatica, the causative agent of fasciolosis, is a global threat to public health, animal welfare, agricultural productivity, and food security.
Clare F. Collett +4 more
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In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Human African trypanosomiasis (HAT), a parasitic protozoal disease, is caused primarily by two subspecies of Trypanosoma brucei. HAT is a re-emerging disease and currently threatens millions of people in sub-Saharan Africa.
William N Setzer, Ifedayo V Ogungbe
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