Results 141 to 150 of about 2,928 (218)

Expanding the scope of synthetic 1,2,4-trioxanes towards Trypanosoma cruzi and Leishmania donovani

Bioorganic and Medicinal Chemistry Letters, 2020
A series of synthetic 1,2,4-trioxanes related to artemisinin was tested against L. donovani and T. cruzi parasites. This screening identified some active compounds, with key common structural features.
Melisa Saye, Claudio A. Pereira, Babu L Tekwani   +2 more
exaly   +2 more sources

Design, Synthesis, Structure‐Activity Relationship and Docking Studies of Novel Functionalized Arylvinyl‐1,2,4‐Trioxanes as Potent Antiplasmodial as well as Anticancer Agents

ChemMedChem, 2020
A novel series of synthetic functionalized arylvinyl‐1,2,4‐trioxanes (8 a–p) has been prepared and assessed for their in vitro antiplasmodial activity against the chloroquine‐resistant Pf INDO strain of Plasmodium falciparum by using a SYBR green‐I ...
Mohit K. Tiwari, P. Coghi, P. Agrawal, B. R. K. Shyamlal, Li Jun Yang, L. Yadav, Y. Peng, Richa Sharma, D. Yadav, D. Sahal, Vincent Kam Wai Wong, S. Chaudhary   +11 more
semanticscholar   +1 more source

Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures

European Journal of Medicinal Chemistry, 2013
Marta Świtalska, Marcel Kaiser, Joanna Wietrzyk   +2 more
exaly   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel 1,2,4‐Trioxanes as Potential Antimalarial Agents

Archiv Der Pharmazie, 2017
Vivek Kumar, Kumkum Srivastava, Anil K Saxena   +2 more
exaly   +2 more sources

Synthesis and Polymerization of Methyl Trioxane and Dimethyl Trioxane

Journal of Macromolecular Science: Part A - Chemistry, 1967
Abstract Methyl trioxane and dimethyl trioxane were synthesized by the cotrimerization of formaldehyde and acetaldehyde. The structures of these two compounds were confirmed by elemental analyses, IR spectra, mass spectra, and NMR spectra. The methyl trioxane was able to polymerize by boron trifluoride etherate, giving a polyoxymethylene, but the ...
Akira Shimizu, Koichiro Hayashi, Seizo Okamura   +2 more
openaire   +1 more source

Piperidine dispiro-1,2,4-trioxane analogues

Bioorganic & Medicinal Chemistry Letters, 2008
Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently used to prepare derivatives (4-7 ...
Sunil, Sabbani, Paul A, Stocks, Gemma L, Ellis, Jill, Davies, Erik, Hedenstrom, Stephen A, Ward, Paul M, O'Neill   +6 more
openaire   +2 more sources

Novel saturated 1,2,4-trioxanes and their antimalarial activity against multidrug resistant Plasmodium yoelii nigeriensis in Swiss mice model via oral route.

Bioorganic & Medicinal Chemistry Letters
Novel saturated 6-(4'-aryloxy phenyl) vinyl 1,2,4-trioxanes 12a(1-3)-12d(1-3) and 13a(1-3)-13d(1-3) have been designed and synthesized, in one single step from diimide reduction of 11a(1-3)-11d(1-3). All the newly synthesized trioxanes were evaluated for
A. Kumari, Priyanka Yadav, Varun Rawat, R. Maurya, Mohammad Shahidul Islam, G. E. Eldesoky, S. K. Puri, V. P. Verma   +7 more
semanticscholar   +1 more source

1,2,3-Triazole tethered 1,2,4-trioxanes: Studies on their synthesis and effect on osteopontin expression in MDA-MB-435 breast cancer cells.

European journal of medicinal chemistry, 2019
Artemisinin and its analogs have shown potent anticancer activity in primary cancer cultures and cell lines by inhibiting cancer proliferation, metastasis, and angiogenesis.
Bala Gangadhar Pasupuleti, Kitboklang Khongsti, B. Das, G. Bez   +3 more
semanticscholar   +1 more source

Polymerization of Trioxane

Angewandte Chemie International Edition in English, 1967
AbstractA survey of the possible modes of polymerization of trioxane is followed by a discussion of current ideas concerning the course of the polymerization. The polymerization, which involves ring cleavage, is characterized by a number of side reactions of the growing polyoxymethylene cations, such as chain transfer, transacetalization, and hydride ...
K. Weissermel, E. Fischer, K. Gutweiler, H. D. Hermann, H. Cherdron   +4 more
openaire   +1 more source

Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy

Drug Resistance Updates, 2005
Thomas Efferth
exaly   +2 more sources