Reduction of the Double Bond of 6‑Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model [PDF]
ACS Omega, 2021 Novel 6-arylethyl-1,2,4-trioxanes6a–i and 7a–i are easily accessible in one step from the diimide reduction of 6-arylvinyl-1,2,4-trioxanes 5a–i. All of these new trioxanes were assessed for their oral antimalarial activity against multidrug-resistant ...
Mohammad Hassam +5 more
doaj +3 more sources
1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action. [PDF]
Pharmaceuticals (Basel), 2022 Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This study
Mendes A +6 more
europepmc +3 more sources
Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine [PDF]
Pharmaceuticals, 2009 Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield.
Theresa A. Shapiro +5 more
doaj +2 more sources
Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug. [PDF]
ACS Omega, 2022 A mechanistic approach to understand the course of metabolism for synthetic 1,2,4-trioxanes, potent antimalarial compounds, to evaluate their bioavailability for antimalarial action has been studied in the present work.
Kumari A +8 more
europepmc +2 more sources
Synthesis and antimalarial activity of 3,3-spiroanellated 5,6-disubstituted 1,2,4-trioxanes. [PDF]
ACS Med Chem Lett, 2013 Maurya R +10 more
europepmc +2 more sources
Trioxane Ingestion in a Child [PDF]
Wilderness & Environmental Medicine, 2020 Trioxane is a stable cyclic trimer of formaldehyde. It is an active ingredient in fuel bars for heating prepackaged foods by military and outdoorspeople. Trioxane depolymerizes to formaldehyde in an acidic environment and is further oxidized to formic acid, which causes neurologic and ocular damage. Because it is solid at room temperature, trioxane is
Jillian L, Theobald +3 more
openaire +2 more sources
Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]
, 2020 A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia +5 more
core +1 more source
Synthesis of Fatty 1,2,4-Trioxanes by Peracetalization of β-Hydroxy Hydroperoxides
Synthesis, 2021 The peracetalization of a β-hydroxy hydroperoxide derived from methyl oleate was studied using benzaldehyde as a model substrate to give the corresponding fatty 1,2,4-trioxane.
N. Duguet +5 more
semanticscholar +1 more source
LMCT-Driven Iron Photocatalysis: Mechanistic Insights and Synthetic Applications. [PDF]
ChemistryLMCT‐driven iron photocatalysis: This review discusses recent developments in ligand‐to‐metal charge transfer (LMCT)‐driven iron photocatalysis, emphasizing mechanistic insights and diverse synthetic applications. By classifying Fe(III)–L bond homolysis pathways, it highlights iron's potential as a sustainable alternative to precious metals for radical‐
Chaudhuri A +4 more
europepmc +2 more sources
Redetermination of 2,4,6-tricyclohexyl-1,3,5-trioxane [PDF]
Acta Crystallographica Section E Structure Reports Online, 2008 Le composé du titre, C(21)H(36)O(3), a été obtenu par traitement du cyclo-hexa-necarbaldéhyde avec de l'acide toluène-4-sulfonique monohydraté catalytique. Cette nouvelle détermination se traduit par une structure cristalline avec une précision significativement plus élevée que la détermination originale [Diana & Ganis (1963▶). Atti Accad. Naz. Lincei,
Rodolfo Moreno‐Fuquen +4 more
openaire +3 more sources