The wisdom of crowds and the repurposing of artesunate as an anticancer drug. [PDF]
, 2015 Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-
Augustin, Y +3 more
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Organic synthesis: march of the machines. [PDF]
, 2015 Organic synthesis is changing; in a world where budgets are constrained and the environmental impacts of practice are scrutinized, it is increasingly recognized that the efficient use of human resource is just as important as material use.
Fitzpatrick, Daniel E +3 more
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Antimalarial sulfone trioxanes
Tetrahedron Letters, 1998 A series of new sulfide and sulfone 1,2,4-trioxanes was prepared in only a few steps from commercial reactants. The sulfone trioxanes were found to have higher in vitro antimalarial potencies than the sulfides, with 12β-arylsulfone trioxanes 1β being from 13 to 14 as potent as the complex natural antimalarial trioxane artemisinin (2).
Gary H. Posner +6 more
openaire +1 more source
Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug [PDF]
, 2011 Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells.
P. Crespo-Ortiz, Maria, Wei, Ming
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CHIMIA, 2009 A concise biography of C. W. Jefford, Professor of Chemistry in Geneva from 1969 to 1994, is given. A personal tribute by the author is paid to Jefford ' s fundamental work in the field of singlet oxygen, endo-peroxides, and 1,2,4-trioxanes as ...
Ulrich Burger
doaj +1 more source
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer [PDF]
, 2008 In the present work, we have investigated the antitumor activity of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on aggressive small cell lung cancer. NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC50
Caccuri, AM +8 more
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Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate [PDF]
, 2016 An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled
Argentine, Mark D. +8 more
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Anticancer activity of the iron facilitator LS081 [PDF]
, 2011 Background Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth.
Zhen Li +3 more
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Stereodynamic Investigation of Labile Stereogenic Centres in Dihydroartemisinin
Molecules, 2010 Since its identification in the early 1970s, artemisinin, as well as semi-synthetic derivatives and synthetic trioxanes, have been used in malaria therapy.
Ilaria D’Acquarica +7 more
doaj +1 more source
Novel perylene derivatives as highly photostable fluorescent dyes [PDF]
, 1994 Perylene-3,4-dicarboxylic imides are prepared by a new decarboxylizing condensation with moderately sterically hindered primary amines. Perylene-3,4-dicarboxylic anhydride is prepared via a saponification reaction of the dicarboximide and is a starting ...
Langhals, Heinz
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