Results 81 to 90 of about 4,964 (161)

The TRIMendous Role of TRIMs in Virus–Host Interactions

Vaccines, 2017
The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes.
Sarah van Tol, Adam Hage, Maria Isabel Giraldo, Preeti Bharaj, Ricardo Rajsbaum   +4 more
doaj   +1 more source

The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion

Viruses
Tripartite motif (TRIM) 25 is a member of the TRIM E3 ubiquitin ligase family, which plays multiple roles in anti-tumor and antiviral defenses through various pathways.
Qianxun Liu, Shantong Peng, Jiani Wei, Zhenzhen Xie   +3 more
doaj   +1 more source

Therapeutic potential of TRIM family proteins in gastric cancer: from signaling pathway regulation to precision targeting strategies

Frontiers in Oncology
Gastric cancer (GC) is a globally prevalent malignant tumor, causing approximately 770,000 deaths in 2020, ranking fourth among all cancers. The tripartite motif (TRIM) protein family is involved in various cellular regulations and has become a key ...
Caiqing Zhao, Jialing Qi, Zhenze Zhang, Qi Feng, Ziling Fang, Nian Fang   +5 more
doaj   +1 more source

Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription

Viruses
Tripartite motif (TRIM) proteins, comprising a family of over 100 members with conserved motifs, exhibit diverse biological functions. Several TRIM proteins influence viral infections through direct antiviral mechanisms or by regulating host antiviral ...
Sheng Shen, Ran Yan, Zhanglian Xie, Xiaoyang Yu, Hongyan Liang, Qiuhong You, Hu Zhang, Jinlin Hou, Xiaoyong Zhang, Yuanjie Liu, Jian Sun, Haitao Guo   +11 more
doaj   +1 more source

TRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway

Scientific Reports
Tumor-associated macrophages play a crucial role in the tumor microenvironment. Tripartite motif 59 (TRIM59), a member of the tripartite motif (TRIM) family, is known to be associated with immunological diseases and macrophage activation.
Haidong Wang, Jun Lou, Hao Liu, Yunlong Liu, Binbin Xie, Wei Zhang, Jiansheng Xie, Hongming Pan, Weidong Han   +8 more
doaj   +1 more source

Additional file 2 of An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer

Supplementary Material ...
Ding, Yixin, Lu, Yangyang, Guo, Jing, Chen, Shuming, Han, Xiaoxi, Wang, Shibo, Zhang, Mengqi, Wang, Rui, Song, Jialin, Wang, Kongjia, Qiu, Wensheng, Qi, Weiwei   +11 more
openaire   +1 more source

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Drug Design, Development and Therapy
Chunyan Weng,1,* Rijuan Jin,1,* Xiaoliang Jin,1,* Zimei Yang,1,* Chenghai He,1,2 Qiuhua Zhang,1 Jingli Xu,1,3 Bin Lv1 1Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang ...
Weng C, Jin R, Jin X, Yang Z, He C, Zhang Q, Xu J, Lv B   +7 more
doaj  

Additional file 1 of An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer

Supplementary Material ...
Ding, Yixin, Lu, Yangyang, Guo, Jing, Chen, Shuming, Han, Xiaoxi, Wang, Shibo, Zhang, Mengqi, Wang, Rui, Song, Jialin, Wang, Kongjia, Qiu, Wensheng, Qi, Weiwei   +11 more
openaire   +1 more source

Novel Missense Variants in <i>TRIM37</i> Associated with Mulibrey Nanism and Complex Congenital Heart Disease. [PDF]

Cardiol Cardiovasc Med
Zodanu GKE, Zeigler AC, Mudery J, Wolf C, Hwang JH, Kang X, Speirs A, Wang LK, Biniwale R, Si MS, Halnon N, Satou GM, UCLA Congenital Heart Defects BioCore Faculty, Grody WW, Van Arsdell GS, Nelson SF, Touma M.   +16 more
europepmc   +1 more source

E3 ubiquitin ligase TRIM47 promotes intrahepatic cholangiocarcinoma progression by ubiquitinating fumarate hydratase and modulating macrophage polarization. [PDF]

J Biol Chem
Fu Y, Wu J, Shi J, Jia C.
europepmc   +1 more source