Results 151 to 160 of about 289,605 (341)
Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing
Advanced Science, EarlyView.Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen +21 morewiley +1 more sourceSupplementary Data from Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer
, 2023 Kim Blenman, Michał Marczyk, Thomas Karn, Qing Tao, Xiaotong Li, Vignesh Gunasekharan, Vesal Yaghoobi, Yalai Bai, Eiman Ibrahim, Tristen Park, Andrea Silber, Denise M. Wolf, Emily Reisenbichler, Carsten Denkert, Bruno V. Sinn, Mariya Rozenblit, Julia Foldi, David L. Rimm, Sibylle Loibl, Lajos Pusztai +19 moreopenalex +1 more sourceRegulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy
Advanced Science, EarlyView.After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li +6 morewiley +1 more sourceSupplementary Table S1. from Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer
, 2023 Ariadna Giró‐Perafita, Sònia Palomeras, David H. Lum, Adriana Blancafort, Gemma Viñas, Glòria Oliveras, Ferran Pérez-Bueno, Ariadna Sarrats, Alana L. Welm, Teresa Puig +9 moreopenalex +1 more sourceMetformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li +9 morewiley +1 more sourceData from Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer
, 2023 Ailed Cruz‐Collazo, Jean F. Ruiz-Calderón, Hector Picon, Luis D. Borrero-García, Irmaris Lopez, Linette Castillo‐Pichardo, María del Mar Maldonado, Jorgé Duconge, Julia I. Medina, Marvin J. Bayro, Eliud Hernandez O'Farril, Cornelis P. Vlaar, Suranganie Dharmawardhane +12 moreopenalex +1 more sourceStochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes
Advanced Science, EarlyView.Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri +8 morewiley +1 more sourceMolecular profiling of breast cancer methylation pattern in triple negative versus non- triple negative breast cancer
Scientific ReportsEpigenetic alterations, especially promotor methylation, have a significant impact on gene expression, molecular subtyping, prognosis, and outcome of breast cancer (BC). The methylation profile was assessed for 22 genes of the BC tissue using the EpiTect Marwa Mohanad, Hager M. Hamza, Abeer A. Bahnassy, Sabry Shaarawy, Ola Ahmed, Hatem A. EL-Mezayen, Eman G. Ayad, Neveen Tahoun, Mona S. Abdellateif +8 moredoaj +1 more sourceData from Activity of Combined Androgen Receptor Antagonism and Cell Cycle Inhibition in Androgen Receptor Positive Triple Negative Breast Cancer
, 2023 Jessica L. Christenson, Kathleen O’Neill, Michelle M. Williams, Nicole S. Spoelstra, Kenneth L. Jones, G. Devon Trahan, Jordan Reese, Elaina T. Van Patten, Anthony Elias, Joel R. Eisner, Jennifer K. Richer +10 moreopenalex +1 more source
