Results 141 to 150 of about 45,296 (245)

The Extract of Rosa roxburghii Tratt Alleviates Pulmonary Fibrosis in Mice via Gut Microbiota‐Amino Acid Metabolism and JAK2/STAT3 Inhibition

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
The ethyl acetate extract of Rosa roxburghii Tratt (EAE) alleviated pulmonary fibrosis through modulation of gut microbiota‐amino acid metabolism and inhibition of the JAK2/STAT3 signaling pathway. Bioactive components and antioxidant capacity were evaluated across different polar extracts of Rosa roxburghii Tratt (RRTEs). The EAE exhibited the highest
Ting Zhou, Heting Zhou, Xinyue Zheng, Xiaomeng Wang, Tao Chen, Xingjie Li, Liqun Wang, Shouqian Li, Yongmei Xie, Lijun Peng, Wenya Yin   +10 more
wiley   +1 more source

Pastinaca sativa L.: Nutritional Composition, Phytochemistry, and Pharmacological Properties Supporting Its Potential as a Functional Food and Therapeutic Agent

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Food‐grade processing of Pastinaca sativa (parsnip) converts a nutrient‐rich plant matrix (dietary fiber, fructans, phenolics) through washing/slicing/enzymatic treatment and ingredient preparation into functional food ingredients, including fiber concentrates, antioxidant‐rich fractions, and parsnip powders/extracts.
Somanjana Khatua, Anish Nag, Surajit Sen, Jit Sarkar, Krishnendu Acharya, Daniela Calina, William N. Setzer, Javad Sharifi‐Rad   +7 more
wiley   +1 more source

Phytochemical Composition, Health Benefits, Functional Properties, and Food Applications of Pumpkin Seeds

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Pumpkin seeds (Cucurbita spp.) are rich in bioactive compounds including proteins, unsaturated fatty acids, dietary fiber, vitamins (E and B‐complex), minerals (zinc, magnesium, iron), and phytochemicals such as phenolics, flavonoids, and phytosterols.
Messenbet Geremew Kassa, Desye Alemu Teferi   +1 more
wiley   +1 more source

Integrated Phytochemical Profiling and Multifunctional Bioactivities of Bellis annua Extracts Obtained by Distinct Extraction Techniques

ChemistryOpen, Volume 15, Issue 5, May 2026.
The present study evaluates the effect of maceration, Soxhlet, and ultrasound‐assisted extraction on the phytochemical composition and biological activities of Bellis annua. LC–ESI–MS/MS analysis revealed chlorogenic acid as the dominant compound, while UAE enhanced flavonoid content and overall antioxidant capacity.
Fatma Ozlem Kargin Solmaz, Cengiz Sarikurkcu, Bektaş Tepe   +2 more
wiley   +1 more source

Asiatic Acid Ameliorates MNNG‐Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis

Phytotherapy Research, Volume 40, Issue 5, Page 2210-2229, May 2026.
ABSTRACT Chronic atrophic gastritis (CAG), a widespread gastrointestinal condition, is widely acknowledged as a precursor to gastric cancer (GC). The incidence of CAG has been steadily increasing, yet effective pharmacological interventions remain unavailable.
Feifei Zhou, Cuiyu Zhu, Wanwan Yuan, Wenkun Peng, Qianqian Xu, Hongli Yang, Ruofan Cao, Ben Wang, Meiqian Wang, Hongwei Xu   +9 more
wiley   +1 more source

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, Volume 40, Issue 5, Page 2710-2729, May 2026.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, Volume 40, Issue 5, Page 2878-2894, May 2026.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

Fucoidan: An Update on Function, Role in Human Health and Applications

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
Fucoidan is a promising bioactive compound with anti‐inflammatory, anticoagulant, anticancer, antioxidant, antiviral, and cardioprotective properties. In addition, thanks to its epigenetic potential, ability to modulate autophagic mechanisms and possibility adjuvant agent or bioactive component of the drug delivery systems, fucoidan is a promising ...
Sharon Critelli, Marilena Celano
wiley   +1 more source

Identification and Geochemical Significance of Novel <i>des</i>-A-Triterpenoids and Mononuclear-Aromatic <i>des</i>-A-Triterpenoids in Tertiary Terrestrial Oils from the Northern of the South China Sea. [PDF]

ACS Omega
Ran Z, Li M, Xiao H, Gao Z, Yuan M, Dong S, Zhang J, Zhao Q, Chen H.   +8 more
europepmc   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source