Results 81 to 90 of about 114,931 (280)

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol, Erice, O., Ferguson, J., Goicoechea, I., Margison, G.P., Wellbrock, C.   +5 more
core   +2 more sources

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Small RNA sequencing of cryopreserved semen from single bull revealed altered miRNAs and piRNAs expression between High- and Low-motile sperm populations [PDF]

, 2017
Putative piRNA clusters that were assigned by proTRAC to the High Motile (HM) and Low Motile (LM) sperm fractions.
A. Stella, B. Lazzari, E. Capra, F. Pizzi, F. Turri, I. Fojadelli, P. Cremonesi, T. M. Gliozzi   +7 more
core   +9 more sources

Methods of Inactivation of SARS-CoV-2 for Downstream Biological Assays

Journal of Infectious Diseases, 2020
The scientific community has responded to the coronavirus disease 2019 (COVID-19) pandemic by rapidly undertaking research to find effective strategies to reduce the burden of this disease.
Edward I. Patterson, T. Prince, Enyia R. Anderson, Aitor Casas-Sánchez, Shirley L. Smith, Cintia Cansado-Utrilla, T. Solomon, M. Griffiths, Á. Acosta-Serrano, L. Turtle, G. Hughes   +10 more
semanticscholar   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Detección molecular del virus de la fiebre amarilla en muestras de suero de casos fatales humanos y en cerebros de ratón.

Biomédica: revista del Instituto Nacional de Salud, 2003
Hemos adaptado un método molecular basado en la técnica de transcripción reversa seguida de la reacción en cadena de la polimerasa (RT-PCR) para diagnóstico alternativo de la infección por el virus de la fiebre amarilla.
Jairo A. Méndez, Gerzaín Rodríguez, María del Pilar Bernal, Dora de Calvache, Jorge Boshell   +4 more
doaj   +1 more source

Generation and characterization of a human iPSC line from a patient with propionic acidemia due to defects in the PCCA gene [PDF]

, 2017
Human induced pluripotent stem cell (iPSC) line was generated from fibroblasts of a patient with propionic acidemia carrying mutations in the PCCA gene: c.1899+4_1899+7delAGTA; p.(Cys616_Val633del) and c.1430 −−?_1643+?del; p.(Gly477Glufs*9 ...
Alonso-Barroso, Esmeralda, Brasil, Sandra, Briso-Montiano, Álvaro, Desviat, Lourdes R., Navarrete, Rosa, Pérez, Belén, Pérez-Cerdá, Celia, Richard, Eva, Ugarte, Magdalena   +8 more
core   +3 more sources

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

Advanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira, Fábio M. de Azevedo, Ingrid G. S. Lins, Janaína C. O. Crispim, Giovanna A. Lira, Rômulo S. Cavalcante, Ricardo Cobucci, Carolina O. Mendes‐Aguiar, Rafaela Torres Dantas Da Silva, Vinícius E. da Silva, Ryan C. Q. Aquino, Raimundo F. Araújo Júnior   +11 more
wiley   +1 more source

Purification and characterisation of dsRNA using ion pair reverse phase chromatography and mass spectrometry [PDF]

, 2017
RNA interference has provided valuable insight into a wide range of biological systems and is a powerful tool for the analysis of gene function. The exploitation of this pathway to block the expression of specific gene targets holds considerable promise ...
Dickman, M.J., Kilby, P.M., Kung, A.-W., Nwokeoji, A.O., Portwood, D.E.   +4 more
core   +1 more source

Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)

Experimental Neurobiology, 2020
The severe acute respiratory coronavirus 2 (SARS-CoV-2), which emerged in December 2019 in Wuhan, China, has spread rapidly to over a dozen countries. Especially, the spike of case numbers in South Korea sparks pandemic worries. This virus is reported to
Joungha Won, Solji Lee, Myungsun Park, Tai Young Kim, M. Park, Byung Yoon Choi, Dongwan Kim, Hyeshik Chang, Won Do Heo, V. N. Kim, C. J. Lee   +10 more
semanticscholar   +1 more source