Results 91 to 100 of about 616,340 (230)

0221 Inc. Photo®

0221 Inc. Photo® captures life’s beauty through stunning visuals, blending artistic creativity with storytelling. Specializing in nature, culture, and architecture, the company celebrates unique perspectives, showcasing breathtaking landscapes and ...
0221 Inc.®
core   +1 more source

Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations

Advances in proteomic assay methodologies and genomics have significantly improved our understanding of the blood proteome. Schizophrenia and psychosis risk are linked to polygenic scores for schizophrenia and other mental disorders, as well as to ...
Bearden, CE, Walker, E., Corcoran, C, Barbee, J., Kane, J.M., Mongan, D., Perkins, DO, Toben, C, Li, Q.S., Roth, S, Nunez, A.R., Wannan, CMJ, Paul Amminger, G, Mongan, D, Khadimallah, I., Kahn, R.S., Clark, SR, Upthegrove, R, Pasternak, O, Shah, J.L., Billah, T., Martin, AR, Bouix, S, Bearden, C.E., Barbee, J, Khadimallah, I, Walker, E, Martin, A.R., McGorry, PD, Wolf, DH, Li, QS, Do, KQ, Clark, S.R., Do, K.Q., Cerrato, F., Nelson, B., Bleggi, RS, Jeffries, CD, Phassouliotis, C., McGorry, P.D., Calkins, M.E., Shenton, M.E., Shah, JL, Anticevic, A, Nunez, AR, Anticevic, A., Winter-van Rossum, I., Cerrato, F, Bouix, S., Woods, SW, Jeffries, C.D., Shenton, ME, Klauser, P, Billah, T, Cotter, D, Cotter, D., Wolf, D.H., Corcoran, C., Kane, JM, Klauser, P., Calkins, ME, Nelson, B, Wray, N.R., Winter-van Rossum, I, Woods, S.W., Ellman, LM, Perkins, D.O., Upthegrove, R., Roth, S., Phassouliotis, C, Bleggi, R.S., Ellman, L.M., Pasternak, O., Toben, C., Wray, NR, Paul Amminger, G., Kahn, RS   +76 more
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TÄMÄ MUUTEN TARTTUU! Teemailta seksuaaliterveydestä Kuopion Tyttöjen Talolla® [PDF]

, 2019
WHO eli World Health Organization on määrittänyt seksuaaliterveyden seuraavasti: Seksuaaliterveys on seksuaalisuuteen liittyvä fyysinen, emotionaalinen, henkinen ja sosiaalinen hyvinvoinnin tila, eikä sillä tarkoiteta vain taudin, toimintahäiriön tai ...
Eronen, Oona, Nissinen, Senni, Rusanen, Taru   +2 more
core  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Strategies for Validation of Inactivation of Viruses with Trizol® LS and Formalin Solutions. [PDF]

Appl Biosaf, 2020
Retterer C, Kenny T, Zamani R, Altamura LA, Kearney B, Jaissle J, Coyne S, Olschner S, Harbourt D.   +8 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy

Frontiers in Immunology
BackgroundIt is documented that Schistosoma mansoni antigens can induce immune responses able to regulate complex diseases. Conversely, the dysregulated inflammatory response in leprosy increases morbidity and leads to reactional episodes, impairing the ...
Joyce Karoline Silva, Joyce Karoline Silva, Lucas Neves de Farias, Lucas Neves de Farias, Tainã Lago, Tainã Lago, Tainã Lago, Luciana dos Santos Cardoso, Luciana dos Santos Cardoso, Ricardo Khouri, Ricardo Khouri, Ricardo Khouri, Ricardo Khouri, Paulo Roberto Machado, Paulo Roberto Machado, Paulo Roberto Machado, Léa Cristina Castellucci, Léa Cristina Castellucci, Léa Cristina Castellucci   +18 more
doaj   +1 more source

Modified CTAB and Trizol Protocols Improve RNA Extraction from Chemically Complex Embryophyta

, 2015
Premise of the study: Here we present a series of protocols for RNA extraction across a diverse array of plants; we focus on woody, aromatic, aquatic, and other chemically complex taxa.
Andre S. Chanderbali, Douglas E. Soltis, Jordon-Thaden, Ingrid E., Soltis, Douglas E., Ingrid E. Jordon‐Thaden, Matthew A. Gitzendanner, Chanderbali, Andre A., Gitzendanner, Matthew A.   +7 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source