Results 111 to 120 of about 616,340 (230)
Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT
Advanced Science, EarlyView.Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv +9 morewiley +1 more sourceEarly Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui +25 morewiley +1 more sourceStage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing
Advanced Science, EarlyView.ABSTRACT
Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen +13 morewiley +1 more sourceCollecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative [PDF]
Speech-based detection of early psychosis is progressing at a rapid pace. Within this evolving field, the Accelerating Medicines Partnership® in Schizophrenia (AMP® SCZ) is uniquely positioned to deepen our understanding of how language and related ...Perkins, Diana O., Cecchi, Guillermo A, Diaz-Caneja, Covadonga M., Thompson, Judy L., Kahn, Rene S., Nelson, Barnaby, Powers, Albert R., Lauren M. Ellman, Daniel Mamah, Gregory P. Strauss, Kambeitz, Joseph, Rene S. Kahn, Corcoran, Cheryl M, Carla Gerber, Steven M. Silverstein, Choi, Jimmy, Louise Birkedal Glenthøj, Cheryl M. Corcoran, Pablo A. Gaspar, Eric Yu Hai Chen, Woods, Scott W., Guillermo A. Cecchi, Cornblatt, Barbara A., Ennis, Michaela, Breitborde, Nicholas J. K., Linying Li, Shah, Jai L, Henecks, Mara, Eduardo Castro, Bilgrami, Zarina R., Dominic Dwyer, Nikolaos Koutsouleris, Pasternak, Ofer, Liebenthal, Einat, Kane, John M., Daniel H. Mathalon, Henry, Tae'lar, Mathalon, Daniel H., Powers, Albert R, Ellman, Lauren M., Carrie E. Bearden, Jun Soo Kwon, Cho, Kang Ik K., Calkins, Monica E, Glenthøj, Louise Birkedal, McGorry, Patrick D, Jack Rogers, Cadenhead, Kristin S., Celso Arango, Albert R. Powers, Pearlson, Godfrey D., Conus, Philippe, Ellman, Lauren M, Perez, Jesus, Mittal, Vijay A., Joseph Kambeitz, Alameda, Luis K., Bearden, Carrie E., Matcheri S. Keshavan, Silverstein, Steven M, Covadonga M. Diaz-Caneja, Gerber, Carla, Shah, Jai L., Bearden, Carrie E, Bilgrami, Zarina R, Scott W. Woods, Sabb, Fred W, Colton, Beau-Luke, Bouix, Sylvain, Zailyn Tamayo, Gaspar, Pablo A, Jason Schiffman, Judy L. Thompson, Godfrey D. Pearlson, Beau-Luke Colton, Alan Anticevic, Hui, Christy, Dwyer, Dominic, Keshavan, Matcheri S., McGorry, Patrick D., Cecchi, Guillermo A., Cornblatt, Barbara A, Arango, Celso, Tae’lar Henry, Christy Hui, Henry, Tae’lar, Zarina R. Bilgrami, Baker, Justin T, Carla Agurto, Phillip M. Wolff, Matthew R. Broome, Kim, Sung-Wan, Addington, Jean, Swapna Verma, Smesny, Stefan, Gaspar, Pablo A., Wolff, Phillip M., Fusar-Poli, Paolo, Kristin S. Cadenhead, Nordentoft, Merete, Kahn, Rene S, Li, Linying, Mathalon, Daniel H, Castro, Eduardo, Horton, Leslie E, John M. Kane, Thompson, Judy L, Calkins, Monica E., Wolff, Phillip M, Leslie E. Horton, Ofer Pasternak, Barnaby Nelson, Mara Henecks, Merete Nordentoft, Verma, Swapna, Fred W. Sabb, Monica E. Calkins, Yassin, Walid, Diaz-Caneja, Covadonga M, Langbein, Kerstin, Shenton, Martha E., Mamah, Daniel, Jijun Wang, Sylvain Bouix, Sabb, Fred W., Martha E. Shenton, Shenton, Martha E, Rogers, Jack, Einat Liebenthal, Eichi, Habiballah Rahimi, Diana O. Perkins, Strauss, Gregory P, Wolf, Daniel H, Rahimi Eichi, Habiballah, Keshavan, Matcheri S, Jesus Perez, Wang, Jijun, Kang Ik K. Cho, Schiffman, Jason, Luis K. Alameda, Baker, Justin T., Corcoran, Cheryl M., Broome, Matthew R, Mittal, Vijay A, Paolo Fusar-Poli, Cho, Kang Ik K, Silverstein, Steven M., Kambeitz-Ilankovic, Lana, Jai L. Shah, Alameda, Luis K, Upthegrove, Rachel, Daniel H. Wolf, Strauss, Gregory P., Isabelle Scott, Billah, Tashrif, Anticevic, Alan, Justin T. Baker, Stone, William S., Jean Addington, Tamayo, Zailyn, Rachel Upthegrove, Koutsouleris, Nikolaos, Lana Kambeitz-Ilankovic, Kwon, Jun Soo, Wolf, Daniel H., Kerstin Langbein, Tashrif Billah, Pearlson, Godfrey D, Stefan Smesny, Woods, Scott W, Kane, John M, Vijay A. Mittal, Sung-Wan Kim, Walid Yassin, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Cadenhead, Kristin S, Horton, Leslie E., Nicholas J. K. Breitborde, Michaela Ennis, Barbara A. Cornblatt, Broome, Matthew R., Jimmy Choi, Breitborde, Nicholas J K, Chen, Eric Yu Hai, Patrick D. McGorry, Habiballah Rahimi Eichi, Scott, Isabelle, Philippe Conus, Stone, William S, William S. Stone, Perkins, Diana O, Agurto, Carla +191 morecore +1 more sourceUltrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis
Advanced Science, EarlyView.We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu +9 morewiley +1 more sourceUltrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis
Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT
The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh +9 morewiley +1 more sourceEfficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage. [PDF]
BMC Genomics, 2013 Simões AE, Pereira DM, Amaral JD, Nunes AF, Gomes SE, Rodrigues PM, Lo AC, D'Hooge R, Steer CJ, Thibodeau SN, Borralho PM, Rodrigues CM. +11 moreeuropepmc +1 more sourceSingle‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer
Advanced Science, EarlyView.Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang +10 morewiley +1 more sourceSurfaces environmental monitoring of SARS-CoV-2: Loop mediated isothermal amplification (LAMP) and droplet digital PCR (ddPCR) in comparison with standard Reverse-Transcription quantitative polymerase chain reaction (RT-qPCR) techniques.
PLoS ONEThe persistence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on substrates, and the impact of fomites on Coronavirus Disease 19 (COVID-19) transmission, is until now, widely discussed.Simona Spiteri, Irene Salamon, Luna Girolamini, Maria Rosaria Pascale, Federica Marino, Carlo Derelitto, Laura Caligaris, Simone Paghera, Manuela Ferracin, Sandra Cristino +9 moredoaj +1 more source
