Results 121 to 130 of about 618,068 (231)

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Surfaces environmental monitoring of SARS-CoV-2: Loop mediated isothermal amplification (LAMP) and droplet digital PCR (ddPCR) in comparison with standard Reverse-Transcription quantitative polymerase chain reaction (RT-qPCR) techniques.

PLoS ONE
The persistence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on substrates, and the impact of fomites on Coronavirus Disease 19 (COVID-19) transmission, is until now, widely discussed.
Simona Spiteri, Irene Salamon, Luna Girolamini, Maria Rosaria Pascale, Federica Marino, Carlo Derelitto, Laura Caligaris, Simone Paghera, Manuela Ferracin, Sandra Cristino   +9 more
doaj   +1 more source

Biological activity of reporter proteins in physiological buffer or TRIzol lysates.

, 2014
Hek293 cells expressing either GFP or Luc were directly lysed in physiological Glo Lysis buffer (GLB) or TRIzol, and GFP or Luc activity were measured. Reporter proteins were verified by western blotting.
Hidenori Nonomura (663023), Hiroko Tada (663025), Yoshito Abe (663027), Haruna Fujiyama (663021), Hirokazu Matsushita (663026), Tomoko Honjo (663024), Junichiro Futami (9387), Rie Kinoshita (663022), Kazuhiro Kakimi (433167)   +8 more
core   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Homotoksikologisen valmisteen (Zeel®) käyttö nivelrikkoisten koirien kivunlievityksessä

, 2005
Nivelrikko on pitkäaikainen, krooninen sairaus, jota ei voida parantaa ja jonka esiintyvyys koirilla on suuri. Sairastuneiden koirien elämänlaatu huononee, käyttö harrastuskoirana ja käyttökoirana loppuu harmillisen aikaisin, ja usein elinaikakin on ...
Kokkonen, Titta A.
core  

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.

Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying prognostic or ...
Yassin, W., Hui, CLM, Kambeitz-Ilankovic, L., Schiffman, J., Kane, J.M., Rogers, J., Bolo, N.R., Smesny, S., Choi, J., Wang, J., Sabb, F.W., Diaz-Caneja, C.M., Laulette, K., Wood, S.J., Gaspar, P.A., Chen, EYH, Stone, W.S., Lindberg, U., Poldrack, R.A., Kubicki, M., Kahn, R.S., Kwon, J.S., Alameda, L., Goncalves, M., Shah, J.L., Kotler, E., Verma, S.K., Wannan, C., Nordentoft, M., Cadenhead, K.S., Cornblatt, B.A., Bearden, C.E., Campbell, D., Koutsouleris, N., Cecchi, G., Arango, C., Mittal, V.A., Langbein, K., Mamah, D., Romo, P.A., Corcoran, C.M., Cannon, T.D., Kapur, T., Horton, L.E., Nelson, B., Zhou, J.H., Strauss, G.P., McGorry, P.D., Rathi, Y., Mathalon, D.H., Calkins, M.E., Shenton, M.E., Markiewicz, C., Ning, L., Anticevic, A., Harms, M.P., Bouix, S., Keshavan, M.S., John, O., Conus, P., Thompson, J.L., Kuperman, J.M., Broome, M.R., Kambeitz, J., Gerber, C., Wolf, D.H., Silverstein, S.M., Haidar, A., Breitborde, NJK, Perez, J., Tamayo, Z., Woods, S.W., Powers, A.R., Hughes, D.E., Wickham, A., Addington, J., Perkins, D.O., Upthegrove, R., Cho, K.K., Kim, N., Fusar-Poli, P., Kim, S.W., Izyurov, I., Ellman, L.M., Glenthøj, L.B., Pasternak, O., Pearlson, G.D.   +86 more
core   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source