Results 11 to 20 of about 116,083 (186)
Role of STAT3 in in vitro transformation triggered by TRK oncogenes. [PDF]
PLoS ONE, 2010 TRK oncoproteins are chimeric versions of the NTRK1/NGF receptor and display constitutive tyrosine kinase activity leading to transformation of NIH3T3 cells and neuronal differentiation of PC12 cells.
Claudia Miranda +6 more
doaj +1 more source
Cell Communication and Signaling, 2021 Background Neurotrophins can activate multiple signalling pathways in neuronal cells through binding to their cognate receptors, leading to neurotrophic processes such as cell survival and differentiation.
Anja Pišlar, Janko Kos
doaj +1 more source
Highlights of the FEBS3+ meeting Exploring molecular frontiers [PDF]
FEBS Open BioFEBS+ meeting Exploring molecular frontiers, held in Pula, Croatia, in autumn 2024 was jointly organized by the Croatian, Finnish, and Swedish Member Societies of the Federation of European Biochemical Societies (FEBS). The congress covered a wide variety of different biochemical themes, some of the highlights of which are presented in this ‘In the ...
Dulić M, Koistinen H, Berntsson R.
europepmc +2 more sources
Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatric Patients
Current Oncology, 2021 Neurotrophic tyrosine receptor kinase gene fusions (NTRK) are oncogenic drivers present at a low frequency in most tumour types (80%) in a small number of rare tumours (e.g., infantile fibrosarcoma [IFS]) and considered mutually exclusive with other ...
Sébastien Perreault +10 more
doaj +1 more source
Superradiant phase transitions with three-level systems [PDF]
, 2012 We determine the phase diagram of $N$ identical three-level systems interacting with a single photonic mode in the thermodynamical limit ($N \to \infty$) by accounting for the so-called diamagnetic term and the inequalities imposed by the Thomas-Reich ...
Baksic, Alexandre +2 more
core +4 more sources
Developmental Neurobiology, 2010 AbstractThe trk family of receptor tyrosine kinases supports survival and differentiation in the nervous system. Paradoxically it has also been shown that members of the trk family can induce cell death in pediatric tumor cells of neuronal origin.
Liraz, Harel +2 more
openaire +2 more sources
Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Adults
Current Oncology, 2021 The tyrosine receptor kinase (TRK) inhibitors larotrectinib and entrectinib were recently approved in Canada for the treatment of solid tumours harbouring neurotrophic tyrosine receptor kinase (NTRK) gene fusions.
D. Gwyn Bebb +17 more
doaj +1 more source
Off-diagonal coefficients of the DeWitt-Schwinger and Hadamard representations of the Feynman propagator [PDF]
, 2005 Having in mind applications to gravitational wave theory (in connection with the radiation reaction problem), stochastic semiclassical gravity (in connection with the regularization of the noise kernel) and quantum field theory in higher-dimensional ...
Antoine Folacci +21 more
core +3 more sources
TRK inhibitors in TRK fusion-positive cancers [PDF]
Annals of Oncology, 2019 TRK fusions are oncogenic drivers of various adult and paediatric cancers. The first-generation TRK inhibitors, larotrectinib and entrectinib, were granted landmark, tumour-agnostic regulatory approvals for the treatment of these cancers in 2018 and 2019, respectively.
openaire +3 more sources
TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer [PDF]
Journal of Cancer, 2021 Tropomyosin receptor kinase (TRK) fusion is one of the oncogenic driver causes of colon cancer, and tropomyosin 3-neurotrophic receptor tyrosine kinase 1 (TPM3-NTRK1) fusion has been detected in the KM12SM cell line. In the present study, we investigated anticancer mechanisms in the KM12SM cell line using three different form of dovitinib (dovitinib ...
Sohn, Sung-Hwa +5 more
openaire +2 more sources