Results 91 to 100 of about 2,911,119 (244)

p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. [PDF]

, 2011
p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA) sub-population of basal keratinocytes.
DALLAGLIO, Katiuscia, LOTTI, Roberta, M. C. Panza, MARCONI, Alessandra, P. Atzei, PALAZZO, ELISABETTA, PINCELLI, Carlo, R. Tiberio, TRUZZI, Francesca, VASCHIERI, Cristina   +9 more
core   +1 more source

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion–Positive Solid Tumors [PDF]

Cancer Discovery, 2017
Abstract Larotrectinib, a selective TRK tyrosine kinase inhibitor (TKI), has demonstrated histology-agnostic efficacy in patients with TRK fusion–positive cancers. Although responses to TRK inhibition can be dramatic and durable, duration of response may eventually be limited by acquired resistance.
Alexander, Drilon, Ramamoorthy, Nagasubramanian, James F, Blake, Nora, Ku, Brian B, Tuch, Kevin, Ebata, Steve, Smith, Veronique, Lauriault, Gabrielle R, Kolakowski, Barbara J, Brandhuber, Paul D, Larsen, Karyn S, Bouhana, Shannon L, Winski, Robyn, Hamor, Wen-I, Wu, Andrew, Parker, Tony H, Morales, Francis X, Sullivan, Walter E, DeWolf, Lance A, Wollenberg, Paul R, Gordon, Dorothea N, Douglas-Lindsay, Maurizio, Scaltriti, Ryma, Benayed, Sandeep, Raj, Bethany, Hanusch, Alison M, Schram, Philip, Jonsson, Michael F, Berger, Jaclyn F, Hechtman, Barry S, Taylor, Steve, Andrews, S Michael, Rothenberg, David M, Hyman   +33 more
openaire   +2 more sources

Precision medicine in cutaneous melanoma—A comprehensive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley   +1 more source

Pyrazolo[1,5-a]pyrimidine as a Prominent Framework for Tropomyosin Receptor Kinase (Trk) Inhibitors—Synthetic Strategies and SAR Insights

Molecules
Tropomyosin receptor kinases (Trks) are transmembrane receptor tyrosine kinases named TrkA, TrkB, and TrkC and encoded by the NTRK1, NTRK2, and NTRK3 genes, respectively.
Amol T. Mahajan, Shivani, Ashok Kumar Datusalia, Carmine Coluccini, Paolo Coghi, Sandeep Chaudhary   +5 more
doaj   +1 more source

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet, Christ, Michael, Eisen, Christoph, Theisen, Karl, Wehling, Martin   +4 more
core   +1 more source

Mammary‐analog secretory carcinoma in children: Surgery or TRK inhibitors first?

Pediatric Blood & Cancer, 2023
AbstractWe report two cases of pediatric mammary‐analog secretory carcinoma (MASC), a male operated on at age 8 and a female operated on at 12, who are in remission 2 years after surgery. The diagnosis of MASC was challenging and established by identifying theETV6::NTRK3fusion transcript in both cases.
Moreddu, Eric, André, Nicolas, Appay, Romain   +2 more
openaire   +3 more sources

Klebsiella sp. strain B7 enhances alkaline tolerance by secreting pyruvic acid to accelerate L‐malic acid accumulation in soybean

Journal of Integrative Plant Biology, EarlyView.
Klebsiella sp. strain B7 acts as a positive regulator in alkaline stress responses in soybean. By activating pyruvic acid metabolism and L‐malic acid biosynthesis pathways, B7 significantly increases alkaline tolerance and yield in soybean. ABSTRACT Alkaline stress is a major constraint on crop growth and development and negatively impacts soybean ...
Yingxue Cao, Yijia Jiang, Yang Li, Yong Long, Siyu Huang, Hongwei Li, Miao Yang, Mingyu Yang, Yuecheng Tang, Bo Zhang, Zhongming Fang, Ming Yuan, Zhenhua Yu, Fanli Meng   +13 more
wiley   +1 more source

Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor

Pharmacology Research & Perspectives
Tropomyosin receptor kinase (Trk) inhibitors are an essential class of anticancer drugs treating NTRK gene fusions‐positive cancer. However, the potential for the emergence of on‐target resistance suggests newer Trk inhibitors with low drug resistance ...
Xiaochen Zhang, Baiyang Yuan, Chunmei Li, Hongbo Wang, Shujuan Wei, Jingwei Tian, Sijin Duan   +6 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

The p75NTR SIGNALING CASCADE MEDIATES MECHANICAL HYPERALGESIA INDUCED BY NERVE GROWTH FACTOR INJECTED INTO THE RAT HIND PAW [PDF]

, 2013
Nerve Growth Factor (NGF) augments excitability of isolated rat sensory neurons through activation of the p75 neurotrophin receptor (p75NTR) and its downstream sphingomyelin signaling cascade, wherein neutral sphingomyelinase(s) (nSMase), ceramide, and ...
Khodorova, Alla, Nicol, Grant D., Strichartz, Gary   +2 more
core   +1 more source