Results 101 to 110 of about 2,911,119 (244)

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post‐Stroke Seizure Susceptibility

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Ischemic stroke induces microglial activation and BDNF–TrkB signaling, leading to KCC2 downregulation and seizure susceptibility. Pharmacological inhibition of microglia or TrkB and restoration of KCC2 function with the chloride extrusion enhancer CLP290 attenuate post‐ischemic seizures.
Jing Zhou, Benjamin H. Wang, Jiangning Yu, Guoxiang Wang, Jingyi Cai, Mohan Yu, Kehua Chen, Li Wan, Xu Liu, Zhigang Yang, Yulong Wang, Yun Wang   +11 more
wiley   +1 more source

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

Neurobiology of Disease, 2007
The anti-Parkinson monoamine oxidase (MAO)-B inhibitor rasagiline (Azilect) was shown to possess neuroprotective activities, involving the induction of brain-derived- and glial cell line-derived neurotrophic factors (BDNF, GDNF).
Yotam Sagi, Silvia Mandel, Tamar Amit, Moussa B.H. Youdim   +3 more
doaj   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P, Lotto, RB, Price, DJ, Vali, L   +3 more
core   +1 more source

From mechanism to phenotype: What fits in a basket trial

Epilepsia, EarlyView.
Kette D. Valente
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

One at a time, live tracking of NGF axonal transport using quantum dots [PDF]

, 2007
Retrograde axonal transport of nerve growth factor (NGF) signals is critical for the survival, differentiation, and maintenance of peripheral sympathetic and sensory neurons and basal forebrain cholinergic neurons.
A. Ramirez, B. Cui, Beattie, Bhattacharyya, Bomont, Bonneau, Bronfman, C. Wu, Campenot, Chan, Claude, Delcroix, E. L. Bearer, Fu, Giepmans, Ginty, Grimes, Hohng, Howe, Korsching, Kuruvilla, L. Chen, Lidke, Miller, Mobley, Pinaud, Reynolds, Reynolds, Rosenberg, S. Chu, Salehi, Sofroniew, Tani, Taylor, Ure, Valdez, von Bartheld, Vu, W. C. Mobley, W.-P. Li, Watson, Weible, Wu, Ye, Zhuang, Zweifel   +45 more
core   +3 more sources

Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG‐TOP2 Study

Cancer Science, Volume 117, Issue 2, Page 522-535, February 2026.
In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Kayoko Tao, Takako Yoshioka, Miho Kato, Kazuyuki Komatsu, Shinichi Tsujimoto, Kenichi Sakamoto, Kazuki Tanimura, Minako Sugiyama, Masahiro Sekiguchi, Yoshiko Nakano, Yoshihiro Otani, Yasushi Yatabe, Akihiko Yoshida, Hajime Okita, Junko Hirato, Kenichi Kohashi, Yukichi Tanaka, Shinji Kohsaka, Takashi Kubo, Kuniko Sunami, Makoto Hirata, Shuichi Tsutsumi, Hiroyuki Aburatani, Katsuyoshi Koh, Masahiro Hirayama, Shuhei Karakawa, Yukayo Terashita, Hiroyuki Fujisaki, Takeshi Yagi, Akihiro Yoneda, Shinji Mochizuki, Hiroyuki Shichino, Tatsuya Suzuki, Tetsuya Takimoto, Koichi Ichimura, Chitose Ogawa, Kimikazu Matsumoto, Hitoshi Ichikawa, Motohiro Kato   +38 more
wiley   +1 more source

Trk inhibitor GNF‑5837 suppresses the tumor growth, survival and migration of renal cell carcinoma.

Oncology Report, 2019
The clinical treatment of renal cell carcinoma (RCC) remains a major challenge. A number of novel agents and therapeutic strategies are currently undergoing active investigation.
Yicheng Chen, Huan Wang, Yuanlei Chen, Mingchao Wang, Guoqing Ding, Tao Li   +5 more
semanticscholar   +1 more source

WHO classification of skin tumours: key updates in the fifth edition

Histopathology, Volume 88, Issue 3, Page 555-568, February 2026.
This review article summarizes the key updates in the 5th edition of the WHO Classification of Skin Tumours. It provides an overview of the major changes and new entities specific to the skin section, covering areas such as epidermal, melanocytic, mesenchymal and other tumours. The 5th edition of the World Health Organization Classification of Tumours (
Gabrielle Goldman‐Lévy, Raymond Barnhill, Boris C. Bastian, Werner Kempf, David Elder, Pedram Gerami, Wayne Grayson, Dmitry Kazakov, Daniela Massi, Jane Messina, Arnaud de la Fouchardière, Alexander J. Lazar, Thomas Brenn, Brian Rous, Andrew Field, Anthony Gill, Jennelle C. Hodge, Joseph D Khoury, Katia Leite, Shahin Sayed, Puay Hoon Tan, Rosalie Elenitsas, Eduardo Calonje, Lyn M. Duncan, Liang Zhiyong, Holger Moch, Rajendra Singh, Harshima Wijesinghe, Ian Cree, Dilani Lokuhetty   +29 more
wiley   +1 more source

Precision Medicine for Pediatric Glioma and NF1-Associated Tumors: The Role of Small Molecule Inhibitors

Current Oncology
Pediatric gliomas encompass the most common brain tumor in children and are subdivided into pediatric low-grade gliomas (pLGGs) and pediatric high-grade gliomas (pHGGs). The era of molecular diagnosis has shifted the treatment paradigms and management of
Samuele Renzi, Julie Bennett, Nirav Thacker, Chantel Cacciotti   +3 more
doaj   +1 more source