Results 151 to 160 of about 35,994 (298)

Expression of Nerve Growth Factor (NGF) and Its Receptors TrkA and p75 in the Reproductive Organs of Laying Hens

Brazilian Journal of Poultry Science, 2016
In order to investigate the expression levels of nerve growth factor (NGF) and its receptors (TrkA and p75) in prehierarchical follicles and oviducts of hens, five 130-day-old laying hens were examined by immunohistochemistry and RT-PCR analysis. NGF and
PU Shaoxia, QU Changwei, LI Zhi, LI Yansen, LI ChunMei   +4 more
doaj   +1 more source

Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Misfolding, Aggregation, and Mutation-dependent Neurodegeneration by Dysfunction of the Autophagic Flux*

Journal of Biological Chemistry, 2016
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder characterized by insensitivity to noxious stimuli and variable intellectual disability (ID) due to mutations in the NTRK1 gene encoding the NGF receptor TrkA ...
M. L. Franco, C. Melero, E. Sarasola, P. Acebo, A. Luque, Isabel Calatayud-Baselga, M. García-Barcina, M. Vilar   +7 more
semanticscholar   +1 more source

Expression of NGF, BDNF and their receptors in subcutaneous adipose tissue of lactating cows [PDF]

, 2015
Currently, there are no reports of neurotrophins in adipose tissue of cows. The distribution of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and their high-affinity tyrosine kinase receptors TrkA and TrkB, was investigated by ...
Colitti, Monica, Loor, Juan Jose, Stefanon, Bruno   +2 more
core   +1 more source

TTF1 suppresses neuroblastoma growth and induces neuroblastoma differentiation by targeting TrkA and the miR-204/TrkB axis

iScience, 2022
Summary: Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children. We found that TTF1, TrkA, and miR-204 were lowly expressed, whereas TrkB was highly expressed in undifferentiated NB tissues.
Tianyou Yang, Jiahao Li, Zhenjian Zhuo, Huijuan Zeng, Tianbao Tan, Lei Miao, Manna Zheng, Jiliang Yang, Jing Pan, Chao Hu, Yan Zou, Jing He, Huimin Xia   +12 more
doaj  

THE RATIO OF TrkA AND p75 RECEPTORS ON THE CELL NEUROEPITHELIAL TUMORS – A NEW TARGET EFFECT OF NERVE GROWTH FACTOR WITH CISPLATIN AND TEMOZOLOMIDE AND THE COMBINATIONS

Опухоли головы и шеи, 2017
Objective. To study the change of expression of TrkA, p75 receptors and their ratio on the human anaplastic astrocytoma, glioblastoma and medulloblastoma cells cultures exposed to nerve growth factor (NGF) and its combination with cisplatin or ...
A. N. Chernov
doaj   +1 more source

The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor

Frontiers in Neuroscience, 2016
The nerve growth factor (NGF) N-terminus peptide, NGF(1–14), and its acetylated form, Ac-NGF(1–14), were investigated to scrutinize the ability of this neurotrophin domain to mimic the whole protein.
G. Pandini, C. Satriano, A. Pietropaolo, F. Gianì, Alessio Travaglia, D. La Mendola, V. Nicoletti, E. Rizzarelli   +7 more
semanticscholar   +1 more source

Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins. [PDF]

, 2018
Clostridium perfringens uses its large arsenal of protein toxins to produce histotoxic, neurologic and intestinal infections in humans and animals. The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (
McClane, Bruce A, Navarro, Mauricio A, Uzal, Francisco A   +2 more
core   +3 more sources

Investigating TrkA Expression in Canine Appendicular Osteosarcoma

Journal of Veterinary Internal Medicine, 2008
Background: The tropomyosin‐related kinase A (TrkA) proto‐oncogene encodes for a receptor that binds with high affinity to the neurotrophin ligand, nerve growth factor (NGF). Intracellular signaling mediated by the TrkA/NGF axis orchestrates neuronal cell differentiation, mitogenesis, and survival. Interestingly, TrkA also is expressed by bone forming
T M, Fan, A M, Barger, I T, Sprandel, R L, Fredrickson   +3 more
openaire   +2 more sources

Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism

Molecular Metabolism, 2022
Objective: Brown adipogenesis and thermogenesis in brown and beige adipose tissue (AT) involve vascular remodeling and sympathetic neuronal guidance. Here, we investigated the molecular mechanism coordinating these processes.
Alexes C. Daquinag, Zhanguo Gao, Yongmei Yu, Mikhail G. Kolonin   +3 more
doaj  

The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells [PDF]

, 1999
Hiroshi Yamashita, Shalom Avraham, Shuxian Jiang, Ivan Đikić, Hava Avraham   +4 more
openalex   +1 more source