Results 271 to 280 of about 34,874 (291)
Some of the next articles are maybe not open access.
Journal of Cellular Biochemistry, 2018
To observe the effect of electroacupuncture on the morphological change of the bladder tissue and the protein expression levels of NGF, TrkA, p‐TrkA, AKT, and p‐AKT in the bladder tissue of rats with neurogenic bladder after suprasacral spinal cord ...
Tong Zhang +4 more
semanticscholar +1 more source
To observe the effect of electroacupuncture on the morphological change of the bladder tissue and the protein expression levels of NGF, TrkA, p‐TrkA, AKT, and p‐AKT in the bladder tissue of rats with neurogenic bladder after suprasacral spinal cord ...
Tong Zhang +4 more
semanticscholar +1 more source
Neuroscience Letters, 2008
Glaucoma (GL) is an optic neuropathy characterized by progressive loss of visual field due to retinal cell death and optic nerve (ON) degeneration, usually in response to abnormal elevated intraocular pressure (EIOP). It has previously demonstrated that cells of the ON express nerve growth factor (NGF) and NGF-receptors.
Sposato, Valentina +5 more
openaire +4 more sources
Glaucoma (GL) is an optic neuropathy characterized by progressive loss of visual field due to retinal cell death and optic nerve (ON) degeneration, usually in response to abnormal elevated intraocular pressure (EIOP). It has previously demonstrated that cells of the ON express nerve growth factor (NGF) and NGF-receptors.
Sposato, Valentina +5 more
openaire +4 more sources
An archaeal trkA homolog near dnaK and dnaJ
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993The first trkA gene homolog in the phylogenetic domain Archaea is reported. The gene is located near the dnaK-dnaJ gene cluster in the genome of Methanosarcina mazei S-6, and encodes a protein homologous to the only other TrkA known, i.e., that of the bacterium Escherichia coli, involved in K+ transport.
Charles B. Dugan +2 more
openaire +3 more sources
Mutational analysis of the TrkA gene in prostate cancer
The Prostate, 1998TrkA, the high affinity, tyrosine kinase receptor for nerve growth factor (NGF) has been implicated as an oncogene in several neoplasms. In prostate cancer, inhibitors of the NGF/TrkA signal pathway results in tumor growth inhibition. In contrast, inhibition of this trk pathway in the normal prostate produces no effect.
Daniel J. George +3 more
openaire +3 more sources
A Radioactive Binding Assay for Inhibitors of trkA Kinase
Analytical Biochemistry, 1997The high-affinity receptor for nerve growth factor (NGF), trkA, is a receptor-linked tyrosine kinase. The binding of NGF to trkA, depending on the context of its environment, can cause beneficial or deleterious responses in the target cells. For example, the activation of trkA in sympathetic and sensory neurons causes the subsequent survival and ...
Robert L. Hudkins +5 more
openaire +3 more sources
Biochemical and Biophysical Research Communications, 2010
Caveolin-1, a main structural protein constituent of caveolae, plays an important role in the signal transduction, endocytosis, and cholesterol transport. In addition, caveolin-1 has conflictive role in the regulation of cell survival and death depending on intracellular signaling pathways.
Eun Joo Jung, Choong Won Kim
openaire +3 more sources
Caveolin-1, a main structural protein constituent of caveolae, plays an important role in the signal transduction, endocytosis, and cholesterol transport. In addition, caveolin-1 has conflictive role in the regulation of cell survival and death depending on intracellular signaling pathways.
Eun Joo Jung, Choong Won Kim
openaire +3 more sources
Constitutive TrkA Activity in Receptor-Overexpressing PC12 Clones
Biochemical and Biophysical Research Communications, 2002We have studied ligand-independent signaling by the nerve growth factor receptor TrkA in PC12 clones, under conditions of receptor overexpression. Our results indicate that TrkA-overexpressing PC12 clones display constitutive receptor activation, involving both the mature, 140-kDa form and the immature, intracellular 110-kDa form of the receptor ...
Leoni C, VALTORTA , FLAVIA
openaire +3 more sources
Toxicology and Applied Pharmacology, 2015
Methylmercury (MeHg) is an environmental toxin which induces cell death specific for the nervous systems. Here we show that MeHg causes neuronal cell death through the suppression of the tropomyosin receptor kinase A (TrkA) pathway, and that compounds activating the TrkA pathway prevent MeHg-induced nerve damage in vitro and in vivo.
Fusako Usuki, Masatake Fujimura
openaire +3 more sources
Methylmercury (MeHg) is an environmental toxin which induces cell death specific for the nervous systems. Here we show that MeHg causes neuronal cell death through the suppression of the tropomyosin receptor kinase A (TrkA) pathway, and that compounds activating the TrkA pathway prevent MeHg-induced nerve damage in vitro and in vivo.
Fusako Usuki, Masatake Fujimura
openaire +3 more sources
Science's STKE, 2007
Nerve growth factor (NGF) binds to two structurally unrelated cell surface receptors, the p75 neurotrophin receptor (p75) and the receptor tyrosine kinase TrkA. p75 increases TrkA’s responsiveness to NGF, and coexpression of the two receptors appears to lead to the formation of binding sites with higher affinity for NGF than that of either
openaire +2 more sources
Nerve growth factor (NGF) binds to two structurally unrelated cell surface receptors, the p75 neurotrophin receptor (p75) and the receptor tyrosine kinase TrkA. p75 increases TrkA’s responsiveness to NGF, and coexpression of the two receptors appears to lead to the formation of binding sites with higher affinity for NGF than that of either
openaire +2 more sources
Reactome - a curated knowledgebase of biological pathways, 2007
D Annibali, S Nasi
openaire +1 more source
D Annibali, S Nasi
openaire +1 more source