Results 201 to 210 of about 45,835 (229)

tRNA‐derived fragments as new players in regulatory processes in yeast

Yeast, 2022
AbstractFor a very long time, RNA molecules were treated as transistory molecules, by which the genetic information flows from DNA to proteins; the model proposed in the 1960s accepted that proteins are both the products and the regulators of gene expression.
Agata Tyczewska, Kamilla Grzywacz
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Biochemical properties and progress in cancers of tRNA‐derived fragments

Journal of Cellular Biochemistry, 2019
AbstracttRNA‐derived small RNAs (tRFs), a kind of noncoding RNAs, are generated from transfer RNAs. tRFs have some types according to their source and sizes. They play important roles in cell life and carcinogenesis. In this paper, we review the biogenesis and biological properties.
Zhongliang Ma, Jinbao Zhou, Yang Shao, Fatemah.A. Jafari, Pengfei Qi, Yanli Li   +5 more
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Identification of tRNA-Derived Fragments in Legumes

The tRNA-derived noncoding RNAs (tncRNAs) belong to the novel class of noncoding RNAs, acting as important components of genome regulatory circuits. In planta, the mechanism of generation and function of tncRNAs is not fully elucidated. Production of important leguminous plants like chickpea, Medicago and soybean is majorly hampered due to different ...
Simran Arora, Sahrish Aftab, Tanu Shree, Shailesh Kumar   +3 more
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tRNA-derived fragments and tRNA halves: The new players in cancers

Cancer Letters, 2019
tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can be divided into tRF-1, tRF-2, tRF-3, tRF-5, and i-tRF; tiRNAs can be divided into 5'tiRNA and 3'tiRNA. Both tRFs and tiRNAs play important roles in tumorigenesis.
Linwen Zhu, Jiaxin Ge, Tianwen Li, Yijing Shen, Junming Guo   +4 more
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PtRFdb: Plant tRNA-Derived Fragments Database

2019
The transfer RNA-derived fragments or tRFs represent a distinct class of small non-coding RNAs, and have been detected in evolutionarily divergent organisms. The role of tRFs in human cancers and infectious diseases as well as in gene regulation has been well established in diverse organisms.
Shafaque Zahra, Shailesh Kumar
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tRFs as Potential Exosome tRNA-Derived Fragment Biomarkers for Gastric Carcinoma

Clinical Laboratory, 2020
Gastric Carcinoma (GC) is one of the common diseases induced by the interaction of genes and environment. Exosomes are potential markers for several health problems, which contain lipids, proteins, long non-coding RNAs, microRNAs (miRNAs), and tRNA-derived fragments (tRFs). The roles of mRNAs and miRNAs in GC have been studied comprehensively; however,
Caifeng, Lin, Linwen, Zheng, Ruolei, Huang, Guohua, Yang, Juyin, Chen, Houqiang, Li   +5 more
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Transfer RNA‐derived fragments as potential exosome tRNA‐derived fragment biomarkers for osteoporosis

International Journal of Rheumatic Diseases, 2018
AbstractAimOsteoporosis is one of the common orthopedic diseases featured in low bone mineral density. Exosomes have been proven to be potential markers for many diseases and health problems. The roles of messenger RNAs and microRNAs in osteoporosis have been comprehensively studied; however, little research has focused on the function of plasma ...
Yan Zhang, Feng Cai, Ju Liu, Hongze Chang, Liang Liu, Anli Yang, Xiaodong Liu   +6 more
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Expression Profiles of tRNA-Derived Fragments and their Potential Roles in Ovarian Endometriosis

Epigenomics, 2019
Aim: Transfer RNA-derived fragments have been reported to play a vital role in disease progression, but their role in the pathogenesis of endometriosis remains unknown. Materials & methods: Small RNA sequencing was conducted in three paired ovarian endometriomas and eutopic endometria. The data from 22 paired samples were validated by quantitative real-
Licong Shen, Xiaxia Hong, Wenjun Zhou, Yi Zhang   +3 more
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tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases

Immunologic Research
TRNA-derived fragments (tRFs) are tiny non-coding RNAs that control gene expression and immunological responses. Initially, the tRFs were thought to be only a byproduct of Transfer RNA (tRNA) degradation. Recent studies highlighted their role in autoimmune diseases like type 1 diabetes (T1D), inflammatory bowel disease (IBD), rheumatoid arthritis (RA),
Akanksha, Kaimwal, Muhammed, Hadish, Anil, Kumar, Ajay, Kumar, Anjana, Munshi   +4 more
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Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk

Cancer Research
Abstract tRNA-derived fragments (tRF) are a class of small noncoding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may affect tRF function, highlighting the need to further ...
Bin Li, Hanting Li, Yan Li, Zhirui Chen, Danyi Zou, Chunyi He, Songqiang Li, Kexin Hu, Caibo Ning, Yanmin Li, Hui Geng, Shuhui Yang, Chaoqun Huang, Xiaojun Yang, Qiuhong Wang, Xu Zhu, Xiangpan Li, Ying Zhu, Meng Jin, Xiaoping Miao, Jianbo Tian   +20 more
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