Results 151 to 160 of about 36,147 (195)

The Emerging Function and Promise of tRNA-Derived Small RNAs in Cancer. [PDF]

J Cancer
Yang N, Li R, Liu R, Yang S, Zhao Y, Xiong W, Qiu L.   +6 more
europepmc   +1 more source

The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope

Natural Sciences, Volume 6, Issue 4, October 2026.
ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley   +1 more source

tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application. [PDF]

Mol Cancer
Zhou M, He X, Zhang J, Mei C, Zhong B, Ou C.   +5 more
europepmc   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, Volume 100, Issue 3, Page 655-671, September 2026.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Expression profiles of urine exosomal tRNA-derived small RNAs and their potential roles in calcium oxalate stone disease. [PDF]

Ann Med Surg (Lond)
Hong SY, Miao LT, Yang YY, Wang SG.
europepmc   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Isoleucyl‐tRNA synthetase 2 (IARS2) stabilizes β‐catenin by reducing its phosphorylation at Ser33/37/Thr41 and ubiquitin‐proteasome degradation, thereby promoting β‐catenin nuclear accumulation and transcriptional activation of downstream targets, including inhibitor of DNA binding 3, lactate dehydrogenase A, and Drosha ribonuclease III.
Xi Yang, Ya Wang, Yanjiao Yi, Yang Yang, Hongjiang Wang   +4 more
wiley   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Correction: Yang et al. The Expression Pattern of tRNA-Derived Small RNAs in Adult <i>Drosophila</i> and the Function of <i>tRF-Trp-CCA-014-H3C4</i> Network Analysis. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 6169. [PDF]

Int J Mol Sci
Yang D, Xiao F, Yuan Y, Li J, Wang S, Fan X, Ni Q, Li Y, Zhang M, Gu X, Yan T, Yang M, He Z.   +12 more
europepmc   +1 more source