Results 91 to 100 of about 404,299 (351)

tRNA Modifications: Impact on Structure and Thermal Adaptation

Biomolecules, 2017
Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules between the informational level of nucleic acids and the functional level of proteins.
Christian Lorenz, Christina E Lünse, M. Mörl   +2 more
semanticscholar   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences. [PDF]

, 2017
External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA.
Li, Wei, LIU, Fenyong, Liu, Yujun, Lu, Sangwei, Sheng, Jingxue, Sun, Xu, Trang, Phong, Vu, Gia-Phong, Xu, Mengqiong, Yang, Zhu   +9 more
core   +2 more sources

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Advanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang   +7 more
wiley   +1 more source

Preparation of Translationally Competent tRNA by Direct Chemical Acylation [PDF]

, 2010
Nonsense codon suppression for unnatural amino acid incorporation requires the preparation of a suppressor aminoacyl-tRNA. Chemical acylation strategies are general but inefficient and arduous. A recent report (J. Am. Chem. Soc.
Dougherty, Dennis A., Duffy, Noah H.
core   +2 more sources

Polyadenylation Complex CFII Recognizes Downstream Cis‐element for Pre‐mRNA Polyadenylation Through Interaction with an RNA‐Binding Protein in Arabidopsis

Advanced Science, EarlyView.
This study investigates the cis‐element in pre‐mRNA recognized by the polyadenylation CFII complex. It elucidates how the CFII complex recognizes the consensus cis‐element downstream of the poly(A) site for pre‐mRNA alternative polyadenylation. This comprehensive research provides novel insights into the interaction between 3′ end processing complexes ...
Ying Cao, Ying Guo, Zhibo Yu, Huajian Nie, Jing Yang, Dingfu Qiu, Qiyu Li, Xu Xin, Chang Cheng, Yan Li, Xudong Shang, Yuling Jiao, Qingshun Quinn Li, Ligeng Ma   +13 more
wiley   +1 more source

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

Stem cell research & therapeutics, 2015
IntroductionAdministration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders.
S. R. Baglio, Koos Rooijers, Danijela Koppers-Lalic, F. Verweij, M. Pérez Lanzón, N. Zini, B. Naaijkens, F. Perut, H. Niessen, N. Baldini, D. Pegtel   +10 more
semanticscholar   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Estimating translational selection in Eukaryotic Genomes [PDF]

, 2009
Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the ...
Adams, Akashi, Akashi, Akashi, Akashi, Akashi, Akashi, Bennetzen, Birdsell, Bulmer, Bulmer, Chamary, Coghlan, Comeron, Cutter, dos Reis, Duret, Eyre-Walker, Eyre-Walker, Friedman, Harpending, Hartl, Holstege, Ikemura, Ikemura, Kanaya, Koonin, L. Wernisch, Lafay, Lander, Lowe, Lynch, M. dos Reis, Maside, Percudani, Reis, Sharp, Sharp, Sharp, Sherry, The C. elegans Sequencing Consortium, Urrutia, Wang, Wright   +43 more
core   +2 more sources

Continuous directed evolution of aminoacyl-tRNA synthetases

Nature Chemical Biology, 2017
Directed evolution of orthogonal aminoacyl-tRNA synthetases (AARSs) enables site-specific installation of non-canonical amino acids (ncAAs) into proteins.
D. Bryson, Chenguang Fan, Li-Tao Guo, Corwin A. Miller, D. Söll, David R. Liu   +5 more
semanticscholar   +1 more source