Kearns‐Sayre syndrome case. Novel 5,9 kb mtDNA deletion
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 Novel 5,9 kb mtDNA deletion was identified for a 20‐year‐old male who presented with classic Kearns‐Sayre syndrome. Different molecular genetic methods were applied to identify the mitochondrial DNA deletion, but obtaining conflicting research results demonstrated the importance of choosing relevant molecular genetic methods. Abstract Background Kearns‐
Kristina Grigalionienė +4 more
wiley +1 more source
Expanding a tyrosyl-tRNA synthetase assay to other aminoacyl-tRNA synthetases
Data in Brief, 2015 Aminoacyl-tRNA synthetases catalyze the attachment of amino acids to their cognate tRNAs. In general, aminoacyl-tRNA synthetase assays require stoichiometric amounts of tRNA, which limits their sensitivity while increasing their cost.
Charles J. Richardson, Eric A. First
doaj +1 more source
Etude de la methionyl-tRNA Synthetase d'Escherichia coli. 3. Dissociation en sous-unites actives par action d'un facteur extrinseque [PDF]
, 1968 Doris Cassio, Jean‐Pierre Waller
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Quantification of Propargylated RNA Nucleosides After Metabolic Labeling Via the Methylation Pathway
ChemBioChem, EarlyView.Methylation is the most prevalent RNA modification, facilitated by S‐adenosyl‐L‐methionine (SAM) and various methyltransferases (MTases). This work uses a clickable SAM analog to investigate nucleoside modifications in HEK293T cells by mass spectrometric analysis after metabolic labeling with propargylselenohomocysteine (PSH).
Nadine A. Kueck +3 more
wiley +1 more source
Visible‐light‐switchable azobenzenes: Molecular design, supramolecular systems, and applications
Natural Sciences, Volume 3, Issue 1, January 2023., 2023 Abstract Photocontrol of functional molecules and supramolecular systems provides promising directions for the development of innovative materials and technologies. Reversible photoswitches that can isomerize among different states play a vital role in such photoresponsive systems. However, the commonly used UV light for triggering the isomerization of
Minghao Gao +3 more
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Reaction of Amino Acid‐tRNA Synthetases with 2′‐Deoxyadenosine Triphosphate [PDF]
, 1969 S K Mitra, Alan H. Mehler
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Structural Biology of RNA and Protein‐RNA Complexes after AlphaFold3
ChemBioChem, EarlyView.AlphaFold is a great research accelerator and hypothesis generator for structural biology and beyond. With the release of AlphaFold3, RNA and protein‐RNA complex structure prediction is readily possible. This review assesses the reliability of these predictions.
Janosch Hennig
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Unexpected Accumulation of ncm\u3csup\u3e5\u3c/sup\u3eU and ncm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU in a \u3cem\u3etrm9\u3c/em\u3e Mutant Suggests an Additional Step in the Synthesis of mcm\u3csup\u3e5\u3c/sup\u3eU and mcm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU [PDF]
, 2011 Background Transfer RNAs are synthesized as a primary transcript that is processed to produce a mature tRNA. As part of the maturation process, a subset of the nucleosides are modified.
Anderson, James T. +3 more
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Acceptor activity of incomplete aggregate molecules of valine tRNA 1 consisting of four fragments [PDF]
, 1969 A.D. Mirzabekov, D. Lastity, A.A. Bayev
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