Results 131 to 140 of about 241,053 (344)
Phenylalanyl-tRNA synthetase deficiency caused by biallelic variants in FARSA gene and literature review [PDF]
, 2023 Ruolan Guo +6 more
openalex +1 more source
A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme
Advanced Science, EarlyView.The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei +12 more
wiley +1 more source
Genes, 2018 Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during protein synthesis, tRNAs are also the source of a heterogeneous class ...
Vera Oberbauer, M. Schaefer
semanticscholar +1 more source
RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis [PDF]
, 2018 Uwe Richter +9 more
openalex +1 more source
Advanced Science, EarlyView.5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi +17 more
wiley +1 more source
The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications
Angewandte Chemie, EarlyView.The dual redox nature of polyphenols enables antioxidant activity and controlled reactive oxygen species (ROS) generation. This review details the biomedical applications of polyphenols in materials such as nanoparticles, coatings, and hydrogels for antimicrobial, tissue regeneration, and cancer therapies.
Jose Bolaños‐Cardet +7 more
wiley +2 more sources
Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxes [PDF]
, 2014 M.‐Eugenia Armengod +8 more
openalex +1 more source
Fidelity of base-pair recognition by a 3′–5′ polymerase: mechanism of the Saccharomyces cerevisiae tRNAHis guanylyltransferase [PDF]
, 2021 Krishna Patel +2 more
openalex +1 more source