Results 131 to 140 of about 404,299 (351)
Molecular Simulations of the Ribosome and Associated Translation Factors
, 2014 The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535) +3 more
core +6 more sources
Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity [PDF]
, 2015 Danny D. Nedialkova, Sebastian A. Leidel
openalex +1 more source
Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease
International Journal of Molecular Sciences, 2018 Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications,
Marisa Pereira +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li +11 more
wiley +1 more source
Methylated nucleosides in tRNA and tRNA methyltransferases
Frontiers in Genetics, 2014 To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic pathways of the majority of tRNA modifications include a methylation step(s).
Hiroyuki eHori
doaj +1 more source
tRNA-DL: A Deep Learning Approach to Improve tRNAscan-SE Prediction Results [PDF]
, 2018 Xin Gao, Zhi Wei, Hákon Hákonarson
openalex +1 more source
Nature Methods, 2015 High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles of small RNAs, but RNAs containing modified nucleosides may escape detection when those modifications interfere with reverse transcription during RNA-seq library ...
A. E. Cozen +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan +12 more
wiley +1 more source
N6-methyladenosine in mRNA disrupts tRNA selection and translation elongation dynamics
Nature Structural &Molecular Biology, 2016 N6-methylation of adenosine (forming m6A) is the most abundant post-transcriptional modification within the coding region of mRNA, but its role during translation remains unknown. Here, we used bulk kinetic and single-molecule methods to probe the effect
Junhong Choi +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee +28 more
wiley +1 more source