Results 151 to 160 of about 404,299 (351)
Aminoacyl‐tRNA synthetases in medicine and disease [PDF]
, 2013 Peng Yao, Paul L. Fox
openalex +1 more source
Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum
Angewandte Chemie, EarlyView.Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo +16 more
wiley +1 more source
Exploring deep phylogenies using protein structure : a dissertation submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand [PDF]
, 2018 Recent times have seen an exponential growth in protein sequence and structure data. The most popular way of characterising newly determined protein sequences is to compare them to well characterised sequences and predict the function of novel sequences ...
Malik, Ashar J
core
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Angewandte Chemie International Edition, EarlyView.Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo +16 more
wiley +1 more source
Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates
Angewandte Chemie International Edition, EarlyView.DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence‐specifically label protein‐coding RNAs, or to knock down expression selectively, with potential applications in basic transcriptome research and in future ...
Sumon Pratihar +4 more
wiley +1 more source
Optimizing DNA extraction protocols for bryophytes: Insights from Orthotrichaceae
Applications in Plant Sciences, EarlyView.Abstract Premise Extracting high‐quality DNA from challenging plant tissues can be hindered by high levels of phenolics, carbohydrates, and other compounds that bind to or coprecipitate with DNA. Bryophytes, due to their small size, tendency to intermix, biochemical richness, and capacity to absorb environmental pollutants and heavy metals, pose unique
Pablo Aguado‐Ramsay +3 more
wiley +1 more source
Animal Research and One Health, EarlyView.This study characterizes a multidrug‐resistant and strong biofilm‐forming Enterococcus faecalis strain obtained from a shrimp sample in Bangladesh. ABSTRACT Enterococcus faecalis is known for its ability to form strong biofilms and its role as an opportunistic pathogen. In this study, we screened and characterized a multidrug‐resistant (MDR) and strong
Md. Ashek Ullah +4 more
wiley +1 more source
Animal Research and One Health, EarlyView.Dietary selenium (Se) deficiency is recognized as a global problem, and exogenous Se supplementation can effectively enrich its levels in animal bodies. Offal tissues are equally important as meat in Se enrichment. Varying properties among Se species require information beyond total Se concentration to fully evaluate health risk/benefits.
Xiaoqing Guo +9 more
wiley +1 more source
Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis
Arthritis &Rheumatology, Accepted Article.Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar +2 more
wiley +1 more source