A primer on tRNAs, tRNA-m<sup>1</sup>A58 modification, and tRNA derivatives in T-cell activation. [PDF]
Front Cell Dev BiolZhao C, Shen J.
europepmc +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The FEBS Journal, EarlyView.The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl +11 more
wiley +1 more source
Elevated tRNA halves in olfactory epithelial cells of patients with schizophrenia. [PDF]
J Clin InvestGumas JT +4 more
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The FEBS Journal, EarlyView.This study investigates the potential of encapsulin as an antigen display platform for the development of a candidate Salmonella vaccine for poultry. Encapsulin constructs were transiently expressed in Nicotiana benthamiana where they accumulated to high levels.
Carly A. Charron +6 more
wiley +1 more source
Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology. [PDF]
Cell Death DisWang H, Zhang J, Jiang C, Xu S.
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3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes
The FEBS Journal, EarlyView.Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut +2 more
wiley +1 more source
The FEBS Journal, EarlyView.FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese +5 more
wiley +1 more source
Mitogenomic Phylogeny and Adaptive Evolution of Snailfishes (Liparidae) Reveal Correlation Between tRNA Rearrangements and Deep-Sea Colonization. [PDF]
Biology (Basel)Wang R, Li A, Che S, Wang H, Liu S.
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Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases
The FEBS Journal, EarlyView.Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek +12 more
wiley +1 more source
Universal paralogs provide a window into evolution before the last universal common ancestor. [PDF]
Cell GenomGoldman AD, Fournier GP, Kaçar B.
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