Results 51 to 60 of about 181,301 (197)
Brünner Beiträge zur Germanistik und Nordistik, 2019 This paper aims to treat the latest novel TYLL by Daniel Kehlmann with an approach of literary studies as well as to make it didactically useful. With regard to the didactic approach, this contribution seeks to offer literary (recommended) instructions ...
Johannes Köck, Jan Trna
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Advanced Science, EarlyView.In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying +16 more
wiley +1 more source
Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function
Angewandte Chemie, EarlyView.Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou +8 more
wiley +2 more sources
Advanced Science, EarlyView.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution
Life, 2015 Transfer RNAs (tRNAs) are small non-coding RNAs with lengths of approximately 70–100 nt. They are directly involved in protein synthesis by carrying amino acids to the ribosome.
Akio Kanai
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Advanced Science, EarlyView.Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner +14 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
Multiple Layers of Stress-Induced Regulation in tRNA Biology
Life, 2016 tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating ...
Hsiao-Yun Huang, Anita K. Hopper
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Maize Anther Development Involves Translated Open Reading Frames From 3′ Untranslated Regions
Advanced Science, EarlyView.This study examined the translation activity across ten stages of maize anther development, integrating transcriptome and small‐peptide data. It linked mutations in translated 3' ORFs to anther sterility, exemplified by Zm00001eb417050_3' ORF (known as APV1). In addition, the data indicated that maize anthers could assimilate CO2 through the stomata in
Chunyu Wang +8 more
wiley +1 more source