Results 51 to 60 of about 345,668 (351)

Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]

, 2013
.Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap, A L’Hernault, A Wilm, AE Simon, Andrew M. Lever, AR Gruber, BI Klasens, D Chen, D Chen, D Yue, D Yue, E Madore, E Matsuo, EC Hutchinson, Emily Manktelow, EV Puglisi, H Heus, HD Cho, J Jia, JC Kenyon, Jonathan Lever, JR Gog, JT Patton, Laura E. Easton, LE Easton, M Barro, M Estes, MA Tortorici, MW Friederich, N Figueroa, P Annamalai, Peter J. Lukavsky, PJ Lukavsky, R Giegé, R Giegé, RC Olsthoorn, S Nishimura, SC Chen, SH Bernhart, Subhajit Biswas, T Nagaike, TW Dreher, TW Dreher, TW Dreher, TW Dreher, Ulrich Desselberger, W Li, Wilson Li   +47 more
core   +1 more source

From elongator tRNA to initiator tRNA. [PDF]

Proceedings of the National Academy of Sciences, 1993
We show that the two most important properties needed for a tRNA to function in initiation in Escherichia coli are its ability to be formylated and its ability to bind to the ribosomal P site. This conclusion is based on conversion of two different elongator tRNAs to ones that can act as initiators in E. coli.
U, Varshney, C P, Lee, U L, RajBhandary
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]

Exploration of Drug Science
Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov, Anna Kozlova, Cyril Alexeev, Mikhail Drenichev   +3 more
doaj   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain [PDF]

, 2000
Protein kinase GCN2 regulates translation in amino acid–starved cells by phosphorylating eIF2. GCN2 contains a regulatory domain related to histidyl-tRNA synthetase (HisRS) postulated to bind multiple deacylated tRNAs as a general sensor of starvation ...
Anderson, James T., Dong, Jinsheng, Garcia-Barrio, Minerva, Hinnebusch, Alan G., Qiu, Hongfang   +4 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

How to Motivate Science Teachers to Use Science Experiments [PDF]

Journal of Systemics, Cybernetics and Informatics, 2012
A science experiment is the core tool in science education. This study describes the science teachers' professional competence to implement science experiments in teaching/learning science.
Josef Trna
doaj  

Didaktika přírodovědy a rámcové vzdělávací programy [PDF]

, 2005
Příspěvek se zabývá ustavením didaktiky přírodovědy jako vědecké disciplíny.Příspěvek se zabývá ustavením didaktiky přírodovědy jako vědecké disciplíny.Paper deals with problem of creating of science education as a ...
Trna Josef
core  

Analysis of the Role of Aminoacyl tRNA Synthetase Genes in Global Protein Synthesis and mRNA Specific Regulation of Translation in Cancer Cells [PDF]

, 2020
Analysis of the Role of Aminoacyl tRNA Synthetase Genes in Global Protein Synthesis and mRNA Specific Regulation of Translation in Cancer Cells Elyse Nguyen, Depts. of Biology and Chemistry, Dipak Poria, & Esta Sterneck, with Dr. Sarah Williams, Dept. of
Nguyen, Elyse, Poria, Dipak, Sterneck, Esta   +2 more
core   +1 more source