Results 51 to 60 of about 298,923 (289)

On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?

Frontiers in Molecular Biosciences, 2021
Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential
Ricardo Ehrlich, Ricardo Ehrlich, Marcos Davyt, Ignacio López, Cora Chalar, Mónica Marín   +5 more
doaj   +1 more source

Didaktika přírodovědy a rámcové vzdělávací programy [PDF]

, 2005
Příspěvek se zabývá ustavením didaktiky přírodovědy jako vědecké disciplíny.Příspěvek se zabývá ustavením didaktiky přírodovědy jako vědecké disciplíny.Paper deals with problem of creating of science education as a ...
Trna Josef
core  

Genetic incorporation of D-Lysine into diketoreductase in Escherichia coli cells [PDF]

, 2012
D-Lysine has been genetically introduced into diketoreductase in E. coli cells by utilization of an orthogonal Ph tRNA /Lysyl-tRNA synthetase pair.
Denghuan Yi, Shuzhen Wang, Xin Yang, Yijun Chen, Zhi Zhi Liu   +4 more
core   +2 more sources

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Oligonucleotide separation techniques for purification and analysis: What can we learn for today's tasks?

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2402-2427, December 2022., 2022
Abstract Nucleic acids are the blueprint of life. They are not only the construction plan of the single cell or higher associations of them, but also necessary for function, communication and regulation. Due to the pandemic, the attention shifted in particular to their therapeutic potential as a vaccine. As pharmaceutical oligonucleotides are unique in
Robert Minkner, Jirayu Boonyakida, Enoch Y. Park, Hermann Wätzig   +3 more
wiley   +1 more source

Transfer RNA genes experience exceptionally elevated mutation rates. [PDF]

, 2018
Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and they are among the most highly conserved and frequently transcribed genes in all living things.
Corbett-Detig, Russell B, Gong, Henry, Hough, Josh, Lowe, Todd M, Roger, Jacquelyn M, Thornlow, Bryan P   +5 more
core  

NAT10 Promotes Gastric Cancer Liver Metastasis by Modulation of M2 Macrophage Polarization and Metastatic Tumor Cell Hepatic Adhesion

Advanced Science, EarlyView.
The N‐acetyltransferase‐10 (NAT10)‐mediated mRNA N4‐acetylcytidine modification enhances the stability of CXCL2 and KLF5 mRNA. Then, secreted CXCL2 promotes M2 macrophage polarization and oncostatin M secretion, activating NAT10 expression via STAT3 signaling.
Chen Chen, Zhangding Wang, Qingfeng Lin, Mengmeng Li, Lei Xu, Yao Fu, Xiaoya Zhao, Zhuang Ma, Jiawen Xu, Shimeng Zhou, Mingyue Zhang, Yun Qian, Linsen Bao, Bo Wang, Meng Wang, Qingqing Ding, Qiang Wang, Shouyu Wang   +17 more
wiley   +1 more source

The kinetic mechanism of bacterial ribosome recycling. [PDF]

, 2017
Bacterial ribosome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (mRNA) and an uncharged transfer RNA (tRNA) cognate to the terminal mRNA codon bound to the 70S ribosome.
Chen, Yuanwei, Cooperman, Barry S., Kaji, Akira, Kaji, Hideko   +3 more
core   +2 more sources

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, EarlyView.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Improved N‐acetylneuraminic acid bioproduction by optimizing pathway for reducing intermediate accumulation

Food Bioengineering, Volume 1, Issue 3-4, Page 205-211, December 2022., 2022
1. To eliminate the extensively accumulated by‐product N‐acetylglucosamine (GlcNAc), the UDP‐GlcNAc epimerase (NeuC) pathway without GlcNAc production was firstly reconstructed and optimized in Bacillus subtilis, and thereby NeuAc titer increased to 5.9 g/L and the by‐product GlcNAc was eliminated. 2.
Haoyu Guo, Rongzhen Tian, Chenyun Wang, Runzhi Zhao, Xueqin Lv, Long Liu, Yanfeng Liu   +6 more
wiley   +1 more source