Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs
Nucleic Acids Research, 2018 Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA.
Zhuojia Chen +9 more
semanticscholar +1 more source
Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]
Exploration of Drug SciencePentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov +3 more
doaj +1 more source
Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 simultaneously binds Glutamyl-Prolyl-tRNA synthetase and scaffold protein aminoacyl tRNA synthetase complex interacting multifunctional protein 3 of the multi-tRNA synthetase complex [PDF]
, 2018 Higher eukaryotes have developed extensive compartmentalization of amino acid (aa) - tRNA coupling through the formation of a multi-synthetase complex (MSC) that is composed of eight aa-tRNA synthetases (ARS) and three scaffold proteins: aminoacyl tRNA ...
Bartlett, Seamus +2 more
core +1 more source
Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]
, 2013 .Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap +47 more
core +1 more source
Evaluační standardy ve fyzikálním vzdělávání. [PDF]
, 2004 Evaluační standardy fyzikálního vzdělávání jsou klíčovou součástí inovované vzdělávací technologie výuky na základních a středních školách. Článek se zabývá definováním, funkcí a tvorbou těchto standardů.Evaluation standards of physics education are the ...
Trna Josef
core
The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]
, 2007 The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T. +2 more
core +2 more sources
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
, 2007 Příspěvek se zabývá vztahem didaktických znalostí obsahu a didaktiky fyziky.Příspěvek se zabývá vztahem didaktických znalostí obsahu a didaktiky fyziky.Paper deals with the relation between pedagogical content knowledge and didactics of ...
Trna Josef
core
The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
core +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source