Results 71 to 80 of about 191,296 (315)
Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts
Advanced Science, EarlyView.This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu +8 more
wiley +1 more source
Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease
Annals of Neurology, EarlyView.Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias +23 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu +3 more
wiley +1 more source
Multiple Layers of Stress-Induced Regulation in tRNA Biology
Life, 2016 tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating ...
Hsiao-Yun Huang, Anita K. Hopper
doaj +1 more source
THE EFFECT OF TRNA CONCENTRATION ON THE RATE OF PROTEIN SYNTHESIS [PDF]
, 1969 W. French Anderson
openalex +1 more source
Selektive chemische Manipulation von Mannosyl‐ und Galaktosyl‐Queuosin in tRNAs lebender Zellen
Angewandte Chemie, EarlyView.Die Q‐Base in der Antikodonschleife bestimmter eukaryotischer tRNA wird weiter mannosyliert und galaktosyliert. Durch die Zufuhr chemisch manipulierter Queuinderivate zeigen wir, dass die zuckermodifizierenden Enzyme die Modifikationschemie mit hoher Regio‐ und Chemoselektivität durchführen. Zusammenfassung Queuosin ist ein hypermodifiziertes Nukleosid,
Alexander Pichler +7 more
wiley +1 more source
Erweiterung des Repertoires an lichtschaltbaren unnatürlichen Aminosäuren für das Enzym‐Engineering
Angewandte Chemie, EarlyView.Enzym‐Engineering mit lichtschaltbaren unnatürlichen Aminosäuren (lsUAs) birgt ein hohes Potenzial für Anwendungen wie die Biokatalyse. Wir erweitern hier das aktuell vorhandene Repertoire mit lsUAs, welche vielseitigere Eigenschaften aufweisen, um den Weg für eine fortschrittlichere Etablierung der Lichtkontrolle in Enzymen zu ebnen. Wir berichten die
Caroline Hiefinger +11 more
wiley +1 more source
γ‐Glutamyl Phosphate Attached to Glutamine‐Specific tRNA [PDF]
, 1969 Michael Wilcox
openalex +1 more source
Nuclear and mitochondrial tRNA-lookalikes in the human genome
Frontiers in Genetics, 2014 We are interested in identifying and characterizing loci of the human genome that harbor sequences resembling known mitochondrial and nuclear tRNAs. To this end, we used the known nuclear and mitochondrial tRNA genes (the tRNA-Reference set) to search ...
Aristeidis G Telonis +3 more
doaj +1 more source
Selective Chemical Manipulation of Mannosyl‐ and Galactosyl‐Queuosine in tRNAs of Living Cells
Angewandte Chemie International Edition, EarlyView.The Q‐base in the anticodon loop of certain eukaryotic tRNA is further mannosylated and galactosylated. Using feeding of chemically manipulated queuine derivatives, we show that the sugar‐modifying enzymes perform the modification chemistry with high regio‐ and chemoselectivity.
Alexander Pichler +7 more
wiley +1 more source