Results 71 to 80 of about 241,053 (344)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Didaktika přírodovědy a rámcové vzdělávací programy [PDF]

, 2005
Příspěvek se zabývá ustavením didaktiky přírodovědy jako vědecké disciplíny.Příspěvek se zabývá ustavením didaktiky přírodovědy jako vědecké disciplíny.Paper deals with problem of creating of science education as a ...
Trna Josef
core  

The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]

, 2007
The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T., Schneider, Claudia, Tollervey, David   +2 more
core   +2 more sources

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

How to Motivate Science Teachers to Use Science Experiments [PDF]

Journal of Systemics, Cybernetics and Informatics, 2012
A science experiment is the core tool in science education. This study describes the science teachers' professional competence to implement science experiments in teaching/learning science.
Josef Trna
doaj  

Analysis of the Role of Aminoacyl tRNA Synthetase Genes in Global Protein Synthesis and mRNA Specific Regulation of Translation in Cancer Cells [PDF]

, 2020
Analysis of the Role of Aminoacyl tRNA Synthetase Genes in Global Protein Synthesis and mRNA Specific Regulation of Translation in Cancer Cells Elyse Nguyen, Depts. of Biology and Chemistry, Dipak Poria, & Esta Sterneck, with Dr. Sarah Williams, Dept. of
Nguyen, Elyse, Poria, Dipak, Sterneck, Esta   +2 more
core   +1 more source

tRNA signatures reveal polyphyletic origins of streamlined SAR11 genomes among the alphaproteobacteria [PDF]

, 2013
Phylogenomic analyses are subject to bias from compositional convergence and noise from horizontal gene transfer (HGT). Compositional convergence is a likely cause of controversy regarding phylogeny of the SAR11 group of Alphaproteobacteria that have ...
Amrine, Katherine C. H., Ardell, David H., Swingley, Wesley D.   +2 more
core   +4 more sources

Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3–mediated gene silencing

Journal of Biological Chemistry, 2019
tRNA fragments (tRFs) and tRNA halves have been implicated in various cellular processes, including gene silencing, translation, stress granule assembly, cell differentiation, retrotransposon activity, symbiosis, apoptosis, and more.
Zhangli Su, Canan Kuscu, Asrar A. Malik, Etsuko Shibata, Anindya Dutta   +4 more
semanticscholar   +1 more source

Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials

Advanced Healthcare Materials, EarlyView.
The production of recombinant proteins represents a fundamental step in the characterisation of marine invertebrate adhesives and in the development of bio‐inspired glues. The association of these proteins with other components such as ions, proteins, polysaccharides, or polymers enables the fabrication of biomaterials for various healthcare ...
Alessandra Whaite, Emilie Duthoo, Mathilde Lefevre, Elise Hennebert, Patrick Flammang   +4 more
wiley   +1 more source

Analysis of the complete mitochondrial genome sequence of Palinura homarus

Mitochondrial DNA. Part B. Resources, 2017
The complete mitochondrial genome sequence of Palinura homarus was obtained using PCR amplification and walking sequencing (GenBank accession no. JN_542716). The complete mitochondrial genome of P.
Bao-hua Xiao, Wuchai Zhang, Wei Yao, Chu-wu Liu, Li Liu   +4 more
doaj   +1 more source