Results 81 to 90 of about 241,053 (344)
5\u27-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5\u27-halves. [PDF]
, 2017 Transfer RNAs (tRNAs) are fundamental adapter components of translational machinery. tRNAs can further serve as a source of tRNA-derived noncoding RNAs that play important roles in various biological processes beyond translation.
Kirino, Yohei, Shigematsu, Megumi
core +1 more source
Regulatory roles of tRNA-derived RNA fragments in human pathophysiology [PDF]
, 2021 Kush Kumar Pandey +7 more
openalex +1 more source
Aminoacyl-tRNA synthetase-induced cleavage of tRNA
Nucleic Acids Research, 1992 Aminoacyl-tRNA synthetases interact with their cognate tRNAs in a highly specific fashion. We have examined the phenomenon that upon complex formation E. coli glutaminyl-tRNA synthetase destabilizes tRNA(Gln) causing chain scissions in the presence of Mg2+ ions. The phosphodiester bond cleavage produces 3'-phosphate and 5'-hydroxyl ends.
S, Beresten, M, Jahn, D, Söll
openaire +3 more sources
Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Advanced Materials, EarlyView.The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar +7 more
wiley +1 more source
Matching tRNA modifications in humans to their known and predicted enzymes
Nucleic Acids Research, 2019 tRNA are post-transcriptionally modified by chemical modifications that affect all aspects of tRNA biology. An increasing number of mutations underlying human genetic diseases map to genes encoding for tRNA modification enzymes. However, our knowledge on
Valérie de Crécy-Lagard +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain [PDF]
, 2000 Protein kinase GCN2 regulates translation in amino acid–starved cells by phosphorylating eIF2. GCN2 contains a regulatory domain related to histidyl-tRNA synthetase (HisRS) postulated to bind multiple deacylated tRNAs as a general sensor of starvation ...
Anderson, James T. +4 more
core +1 more source
Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria. [PDF]
, 2016 BackgroundWhile the CCA sequence at the mature 3' end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes.
Ardell, David H, Hou, Ya-Ming
core +3 more sources
Emerging functional principles of tRNA-derived small RNAs and other regulatory small RNAs [PDF]
, 2023 Qi Chen, Tong Zhou
openalex +1 more source
7-Methylguanosine Modifications in Transfer RNA (tRNA)
International Journal of Molecular Sciences, 2018 More than 90 different modified nucleosides have been identified in tRNA. Among the tRNA modifications, the 7-methylguanosine (m7G) modification is found widely in eubacteria, eukaryotes, and a few archaea.
Chie Tomikawa
semanticscholar +1 more source