Results 41 to 50 of about 110,116 (296)
Glutaredoxin GRXS17 associates with the cytosolic iron-sulfur cluster assembly pathway [PDF]
, 2016 Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions.
Cammue, Bruno PA +18 more
core +2 more sources
Bacterial wobble modifications of NNA‐decoding tRNAs [PDF]
IUBMB Life, 2019 AbstractNucleotides of transfer RNAs (tRNAs) are highly modified, particularly at the anticodon. Bacterial tRNAs that read A‐ending codons are especially notable. The U34 nucleotide canonically present in these tRNAs is modified by a wide range of complex chemical constituents.
Emil M. Nilsson, Rebecca W. Alexander
openaire +2 more sources
PLoS Genetics, 2020 Codon usage bias is a universal feature of all genomes and plays an important role in regulating protein expression levels. Modification of adenosine to inosine at the tRNA anticodon wobble position (I34) by adenosine deaminases (ADATs) is observed in ...
Xueliang Lyu +6 more
doaj +1 more source
The first apicoplast tRNA thiouridylase plays a vital role in the growth of Toxoplasma gondii
Frontiers in Cellular and Infection Microbiology, 2022 Toxoplasmosis caused by the protozoan Toxoplasma gondii is one of the most common parasitic diseases in humans and almost all warm-blooded animals. Lys, Glu, and Gln-specific tRNAs contain a super-modified 2-thiourea (s2U) derivatives at the position 34,
Yimin Yang +10 more
doaj +1 more source
FabR regulates Salmonella biofilm formation via its direct target FabB [PDF]
, 2016 Background: Biofilm formation is an important survival strategy of Salmonella in all environments. By mutant screening, we showed a knock-out mutant of fabR, encoding a repressor of unsaturated fatty acid biosynthesis (UFA), to have impaired biofilm ...
De Coster, David +8 more
core +4 more sources
Toxics, 2019 Living organisms respond to environmental changes and xenobiotic exposures by regulating gene expression. While heat shock, unfolded protein, and DNA damage stress responses are well-studied at the levels of the transcriptome and proteome, tRNA-mediated ...
Sabrina M. Huber +3 more
doaj +1 more source
Scientific Reports, 2021 tRNAs and tRNA-derived RNA fragments (tRFs) play various roles in many cellular processes outside of protein synthesis. However, comprehensive investigations of tRNA/tRF regulation are rare.
Zefang Sun +16 more
doaj +1 more source
The Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome-associated Human Mitochondrial tRNALeu(UUR) Mutation Causes Aminoacylation Deficiency and Concomitant Reduced Association of mRNA with Ribosomes [PDF]
, 2000 The pathogenetic mechanism of the mitochondrial tRNALeu(UUR) A3243G transition associated with the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome has been investigated in transmitochondrial cell lines ...
Attardi, Giuseppe +4 more
core +1 more source
PLoS ONE, 2020 Posttranscriptional modification of tRNA is critical for efficient protein translation and proper cell growth, and defects in tRNA modifications are often associated with human disease.
Holly M Funk +9 more
doaj +1 more source
tRNAs as a Driving Force of Genome Evolution in Yeast
Frontiers in Microbiology, 2021 Transfer RNAs (tRNAs) are widely known for their roles in the decoding of the linear mRNA information into amino acid sequences of proteins. They are also multifunctional platforms in the translation process and have other roles beyond translation ...
Ana Rita Guimarães +6 more
doaj +1 more source