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tRNA wobble modifications and protein homeostasis [PDF]
Translation, 2016 tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring efficient protein synthesis, maintaining protein homeostasis, and helping cell adaptation and survival.
Namit Ranjan, Marina Rodnina
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Cooperativity between different tRNA modifications and their modification pathways
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2018Ribonucleotide modifications perform a wide variety of roles in synthesis, turnover and functionality of tRNA molecules. The presence of particular chemical moieties can refine the internal interaction network within a tRNA molecule, influence its thermodynamic stability, contribute novel chemical properties and affect its decoding behavior during mRNA
Raffael Schaffrath +2 more
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tRNA modifications and islet function
Diabetes, Obesity and Metabolism, 2018Efficient and accurate protein translation is essential to producing insulin in pancreatic β‐cells. Transfer RNA (tRNA) is known as the key component of the protein translational machinery. Interestingly, tRNA contains a wide variety of chemical modifications, which are posttranscriptionally catalysed by tRNA modifying enzymes.
Fan‐Yan Wei, Kazuhito Tomizawa
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Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease [PDF]
International Journal of Molecular Sciences, 2018 Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes.
Ana Sofia Varanda +2 more
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Patterns of Base Modification in tRNA
Nature New Biology, 1973WE have previously demonstrated that the N-hydroxy-succinimide ester of phenoxyacetic acid (HSP) reacts with certain species of rat liver tRNA1. The reactive species were identified by an alteration in their elution pattern on benzoylated DEAE-cellulose chromatography.
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Interplay Between tRNA Modifications and Processing
Journal of Molecular BiologyTransfer RNAs play a key role during protein synthesis by decoding genetic information at the translating ribosome. During their biosynthesis, tRNA molecules undergo numerous processing steps. Moreover, tRNAs represent the RNA class that carries the largest variety and highest relative number of chemical modifications.
Jirka Peschek, Francesca Tuorto
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Role of tRNA modification in translational fidelity
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990In transfer RNA many different modified nucleosides are found, especially in the anticodon region. In this region, pseudouridine (psi) is found in positions 38, 39 or 40 in a subset of tRNA species, 2-methylthio-6-hydroxyisopentenyladenosine (ms2io6A) is found in position 37 in tRNAs that read codons starting with U and 1-methylguanosine (m1G) is found
T G, Hagervall +4 more
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tRNA modifications and their potential roles in pancreatic cancer
Archives of Biochemistry and Biophysics, 2021Since the breakthrough discovery of N6-methyladenosine (m6A), the field of RNA epitranscriptomics has attracted increasing interest in the biological sciences. Transfer RNAs (tRNAs) are extensively modified, and various modifications play a crucial role in the formation and stability of tRNA, which is universally required for accurate and efficient ...
Hua Huang +4 more
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Role of tRNA modifications in human diseases
Trends in Molecular Medicine, 2014Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates that tRNA modifications and the enzymes catalyzing such modifications may play important roles in complex human pathologies.
Adrian Gabriel, Torres +2 more
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tRNA Modification: Is Cancer Having a Wobble?
Trends in Cancer, 2017Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis. Recent work has highlighted the surprising upregulation of the wobble uridine 34 (U34) tRNA cascade in cancer, which underlies the specific ...
Rapino, Francesca +4 more
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