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Dynamic Regulation of tRNA Modifications in Cancer
2018Transfer RNAs are decorated by chemical modifications of their nucleosides. These modifications affect all aspects of tRNA biology including translation and tRNA turnover. Interestingly, it was discovered decades ago that levels of modified tRNA nucleosides are changed in cancer patients and that the activity of modifying enzymes varies along with an ...
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[18] Modification of tRNA's by bromination
1971Publisher Summary This chapter discusses the modification of tRNAs through bromination. Among the major bases in tRNA, uracil and cytosine are most susceptible to bromination at room temperature and pH 5.4. Guanine is much less reactive, and adenine is completely resistant to bromination under these experimental conditions, or when the reaction is ...
P.C. Zamecnik, C.T. Yu
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[17] Modification of tRNA with ethylenimine
1971Publisher Summary This chapter describes the chemical modifications of Escherichia coli B tRNA with ethylenimine, which inhibits the ability of E.coli B tRNA to accept certain amino acids. Exposure of unfractionated E. coli B tRNA to ethylenimine at pH 8.0 leads to the aminoethylation of SUMP and GMP residues, and the rate of alkylation of these ...
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Dynamic tRNA Modification Landscape
2016Eukaryotic tRNAs contain on average 14 modified nucleotides per molecule. Modifications in tRNAs are responsible for their structure and their function. During stress, tRNAs have been shown to modulate and reprogram their tRNA status in order to fine-tune translational cellular responses.
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The expanding world of tRNA modifications and their disease relevance
Nature Reviews Molecular Cell Biology, 2021Tsutomu Suzuki, Suzuki Tsutomu
exaly
Alteration of tRNA Modification in Eukaryotes: Causes and Consequences
1983To evaluate the role of the modified nucleosides in tRNA function, especially their involvement in regulatory mechanisms of development, differentiation, or neoplastic transformation we use the following organisms: eubacteria, the slime mold D. discoideum, the topminnow Xiphophorus, and mice.
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