Results 31 to 40 of about 55,541 (288)
P348 tRNA modifications in Candida virulence
Medical Mycology, 2022 Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Candida albicans is a normal commensal of the gastrointestinal tract, but also an important opportunistic pathogen that can cause life-threatening infections. An important pathogenicity factor of C.
Böttcher, Bettina +2 more
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Posttranscriptional modification of tRNA in psychrophilic bacteria [PDF]
Journal of Bacteriology, 1997 Posttranscriptional modification in tRNA is known to play a multiplicity of functional roles, including maintenance of tertiary structure and cellular adaptation to environmental factors such as temperature. Nucleoside modification has been studied in unfractionated tRNA from three psychrophilic bacteria (ANT-300 and Vibrio sp.
J J, Dalluge +5 more
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Preparation of Yeast tRNA Sample for NMR Spectroscopy
Bio-Protocol, 2020 Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs.
Marjorie Catala +3 more
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Life, 2022 The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modifications coevolved with the code.
Lei Lei, Zachary Frome Burton
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tRNA Metabolism and Lung Cancer: Beyond Translation
Frontiers in Molecular Biosciences, 2021 Lung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment ...
Meng Bian +3 more
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tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human disease. [PDF]
Cell Biol ToxicoltRNAs are codon decoders that convert the transcriptome into the proteome. The field of tRNA research is excited by the increasing discovery of specific tRNA modifications that are installed at specific, evolutionarily conserved positions by a set of specialized tRNA-modifying enzymes and the biogenesis of tRNA-derived regulatory fragments (tsRNAs ...
Wu D +7 more
europepmc +3 more sources
Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications. [PDF]
Nat Chem Biol, 2020 Chemical modifications of the nucleosides that comprise transfer RNAs are diverse. However, the structure, location and extent of modifications have been systematically charted in very few organisms. Here, we describe an approach in which rapid prediction of modified sites through reverse transcription-derived signatures in high-throughput transfer RNA-
Kimura S, Dedon PC, Waldor MK.
europepmc +5 more sources
Charging the code — tRNA modification complexes
Current Opinion in Structural Biology, 2019 All types of cellular RNAs are post-transcriptionally modified, constituting the so called 'epitranscriptome'. In particular, tRNAs and their anticodon stem loops represent major modification hotspots. The attachment of small chemical groups at the heart of the ribosomal decoding machinery can directly affect translational rates, reading frame ...
Rościsław Krutyhołowa +2 more
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tRNA modifications regulate translation during cellular stress [PDF]
FEBS Letters, 2014 The regulation of gene expression in response to stress is an essential cellular protection mechanism. Recent advances in tRNA modification analysis and genome‐based codon bias analytics have facilitated studies that lead to a novel model for translational control, with translation elongation dynamically regulated during stress responses.
Gu, Chen +2 more
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On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?
Frontiers in Molecular Biosciences, 2021 Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential
Ricardo Ehrlich +5 more
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