Unstabilized Azomethine Ylides for the Stereoselective Synthesis of Substituted Piperidines, Tropanes, and Azabicyclo[3.1.0] Systems [PDF]
, 2016 Acid treatment of densely substituted 2-silyl-1,2-dihydropyridines provides a new and convenient entry to reactive azomethine ylides that can (1) be protonated and reduced with high stereoselectivity to give piperidines, (2) participate in [3 + 2 ...
Robert G. Bergman (1323120) +3 more
core +7 more sources
Enantiocontrolled Synthesis of Highly Functionalized Tropanes via [5 + 2] Cycloaddition to η3-Pyridinylmolybdenum π-Complexes [PDF]
, 2016 A chiral, nonracemic η3-pyridinyl scaffold participates in [5 + 2] cycloaddition with electron-deficient alkenes, an allene, and an alkyne to give η3-allylmolybdenum bicyclic adducts. The adducts can be demetalated, providing a convergent route to highly
Lanny S. Liebeskind (1867210) +1 more
core +7 more sources
Asymmetric Synthesis of Tropanes by Rhodium-Catalyzed [4 + 3] Cycloaddition [PDF]
, 2016 Rhodium-catalyzed [4 + 3] cycloaddition between methyl 2-(siloxy)vinyldiazoacetate and pyrroles results in the enantioselective synthesis of highly functionalized 8-azabicyclo[3.2.1]octa-2,6-dienes (tropanes).
Ravisekhara P. Reddy (2478823) +1 more
core +1 more source
6β-Acyloxy(nor)tropanes: Affinities for Antagonist/Agonist Binding Sites on Transfected and Native Muscarinic Receptors [PDF]
, 2016 A series of esters of 6β-hydroxynortropane and the N-methyl analogue 6β-tropanol were synthesized and screened versus binding of an antagonist (quinuclidinyl benzilate) and an agonist (oxotremorine-M) at sites on human m1-, m2-, m3-, and m4-muscarinic ...
William L. Padgett (3014064) +3 more
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Stereoselective Synthesis of Tropanes via a Retro-6 p Electrocyclic Ring-Opening / Huisgen [3+2]-Cycloaddition Cascade of Monocyclopropanated Heterocycles. Stereoselektive Synthese von Tropanen über eine 6π-elektrocyclische Ringöffnung/ Huisgen-[3+2]-Cycloadditionskaskade von monocyclopropanierten Heterocyclen [PDF]
, 2020 The synthesis of tropanes via a microwave-assisted, stereoselective 6 pi-electrocyclic ring-opening/ Huisgen [3+2]-cycloaddition cascade of cyclopropanated pyrrole and furan derivatives with electron-deficient dipolarophiles is demonstrated.
Reiser, Oliver +4 more
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Enantioselective Synthesis of Functionalized Tropanes by Rhodium(II) Carboxylate-Catalyzed Decomposition of Vinyldiazomethanes in the Presence of Pyrroles [PDF]
, 2016 A series of enantiomerically enriched tropanes was synthesized by the rhodium(II) octanoate-catalyzed reaction of various N-BOC-protected pyrroles with vinyldiazomethanes.
Nicholas J. S. Huby (3010071) +6 more
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Quantitative results of incorporation of radiolabel (14C) from U-[14C]-sucrose into tropanes (tropine and pseudotropine) by rootless shoots (twigs) of W. somnifera. [PDF]
, 2013 Quantitative results of incorporation of radiolabel (14C) from U-[14C]-sucrose into tropanes (tropine and pseudotropine) by rootless shoots (twigs) of W. somnifera.
Amit Kumar Kushwaha (463088) +5 more
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Synthesis, Monoamine Transporter Binding Properties, and Behavioral Pharmacology of a Series of 3β-(Substituted phenyl)-2β-(3‘-substituted isoxazol-5-yl)tropanes [PDF]
, 2016 Several 3β-(substituted phenyl)-2β-(3-substituted isoxazol-5-yl)tropanes (3a−t) were evaluated for their ability to inhibit radioligand binding at the DAT, 5-HTT, and NET as well as in gross observation and locomotor activity in mice and in rats trained ...
Gerald T. Pollard (2283136) +4 more
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Chemical Synthesis and Pharmacology of 6- and 7-Hydroxylated 2-Carbomethoxy-3-(p-tolyl)tropanes: Antagonism of Cocaine's Locomotor Stimulant Effects [PDF]
, 2016 In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, efforts were made to further capitalize on our earlier finding regarding the ability of a 7-methoxylated pseudococaine analogue to act as a weak ...
Kenneth M. Johnson (2651548) +4 more
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Synthesis, Monoamine Transporter Binding, Properties, and Functional Monoamine Uptake Activity of 3β-[4-Methylphenyl and 4-Chlorophenyl]-2β-[5-(Substituted phenyl)thiazol-2-yl]tropanes [PDF]
, 2016 Synthetic methods were developed for the synthesis of the 3β-(4-substituted phenyl)-2β-[5-(substituted phenyl)thiazol-2-yl]tropanes (4a−s). The compounds were evaluated for their monoamine transporter binding and monoamine uptake inhibition properties ...
Hernán A. Navarro (2447089) +6 more
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