Results 11 to 20 of about 928 (164)

Unstabilized Azomethine Ylides for the Stereoselective Synthesis of Substituted Piperidines, Tropanes, and Azabicyclo[3.1.0] Systems

, 2016
Acid treatment of densely substituted 2-silyl-1,2-dihydropyridines provides a new and convenient entry to reactive azomethine ylides that can (1) be protonated and reduced with high stereoselectivity to give piperidines, (2) participate in [3 + 2 ...
Robert G. Bergman (1323120), Jonathan A. Ellman (610362), Michael A. Ischay (1990174), Michael K. Takase (1371342)   +3 more
core   +4 more sources

Enantiocontrolled Synthesis of Highly Functionalized Tropanes via [5 + 2] Cycloaddition to η³-Pyridinylmolybdenum π-Complexes

, 2016
A chiral, nonracemic η3-pyridinyl scaffold participates in [5 + 2] cycloaddition with electron-deficient alkenes, an allene, and an alkyne to give η3-allylmolybdenum bicyclic adducts. The adducts can be demetalated, providing a convergent route to highly
Lanny S. Liebeskind (1867210), Helena C. Malinakova (1915663)   +1 more
core   +4 more sources

Stereoselective Synthesis of Tropanes via a Retro-6 p Electrocyclic Ring-Opening / Huisgen [3+2]-Cycloaddition Cascade of Monocyclopropanated Heterocycles. Stereoselektive Synthese von Tropanen über eine 6π-elektrocyclische Ringöffnung/ Huisgen-[3+2]-Cycloadditionskaskade von monocyclopropanierten Heterocyclen [PDF]

, 2020
The synthesis of tropanes via a microwave-assisted, stereoselective 6 pi-electrocyclic ring-opening/ Huisgen [3+2]-cycloaddition cascade of cyclopropanated pyrrole and furan derivatives with electron-deficient dipolarophiles is demonstrated.
Reiser, Oliver, Ertl, Thomas, Eckl, Robert, Sonnleitner, Carina M., Park, Saerom   +4 more
core   +1 more source

Asymmetric Synthesis of Tropanes by Rhodium-Catalyzed [4 + 3] Cycloaddition

, 2016
Rhodium-catalyzed [4 + 3] cycloaddition between methyl 2-(siloxy)vinyldiazoacetate and pyrroles results in the enantioselective synthesis of highly functionalized 8-azabicyclo[3.2.1]octa-2,6-dienes (tropanes).
Ravisekhara P. Reddy (2478823), Huw M. L. Davies (1336170)   +1 more
core   +1 more source

6β-Acyloxy(nor)tropanes:  Affinities for Antagonist/Agonist Binding Sites on Transfected and Native Muscarinic Receptors

, 2016
A series of esters of 6β-hydroxynortropane and the N-methyl analogue 6β-tropanol were synthesized and screened versus binding of an antagonist (quinuclidinyl benzilate) and an agonist (oxotremorine-M) at sites on human m1-, m2-, m3-, and m4-muscarinic ...
William L. Padgett (3014064), John W. Daly (2309572), Tara H. Gupta (3024150), Xue-Feng Pei (3024147)   +3 more
core   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

Unravelling Mechanisms of Acquired Drought Tolerance by Priming in Tomato Using Integrative Multi‐Omics Phenotypic Analysis

Plant Biotechnology Journal, EarlyView.
ABSTRACT The escalating frequency and intensity of recent droughts threaten global crop production and food security. Although drought priming is crucial for plant drought resilience, the mechanisms imparting drought stress memory remain poorly understood, especially in crops such as tomato. This study elucidates the mechanisms of drought stress memory
Rong Zhou, Yankai Li, Ge Wang, Hong Chen, Xiaqing Yu, Yinlei Wang, Xuedong Yang, Zhen Lyu, Trupti Joshi, Xiaoming Song, Carl‐Otto Ottosen, Ian Charles Dodd, Ron Mittler, Fangling Jiang, Zhen Wu   +14 more
wiley   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source