Results 31 to 40 of about 928 (164)
A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 357-374, August 2026.Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel +3 more
wiley +1 more source
, 2016 In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, efforts were made to further capitalize on our earlier finding regarding the ability of a 7-methoxylated pseudococaine analogue to act as a weak ...
Kenneth M. Johnson (2651548) +4 more
core +2 more sources
Food Science &Nutrition, Volume 14, Issue 8, August 2026.Overview of MSG‐assisted GABA enrichment and associated changes in amino acid, fatty acid, and volatile metabolite profiles in germinated black highland barley. ABSTRACT γ‐Aminobutyric acid (GABA) is a functional amino acid with multiple health benefits; however, the mechanism of its enrichment in black highland barley, particularly through precursor ...
Xiaohang Lu, Nana Ma, Yuan Wang
wiley +1 more source
ChemistryOpen, Volume 15, Issue 8, August 2026.Low‐molecular‐weight phenolic acids in M. autumnalis were associated with antioxidant activity, AChE, and hCA inhibition effects, whereas flavonoid‐rich S. junceum displayed BChE‐oriented inhibition effect and antibacterial activity. LC‐MS/MS‐based metabolite profiling linked distinct chemical compositions to bioactivity patterns, supporting further ...
Kubra Aslan +5 more
wiley +1 more source
, 2016 Synthetic methods were developed for the synthesis of the 3β-(4-substituted phenyl)-2β-[5-(substituted phenyl)thiazol-2-yl]tropanes (4a−s). The compounds were evaluated for their monoamine transporter binding and monoamine uptake inhibition properties ...
Hernán A. Navarro (2447089) +6 more
core +1 more source
Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance
New Phytologist, Volume 251, Issue 3, Page 975-995, August 2026.Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap +3 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 8, Page 4823-4843, August 2026.ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu +13 more
wiley +1 more source
, 2016 Cocaine is a potent stimulant of the central nervous system. Its reinforcing and stimulant effects are related to its ability to inhibit the membrane bound dopamine transporter (DAT).
Bertha K. Madras (2649703) +7 more
core +1 more source
Reaction Enumeration Based on NBO‐Informed Molecular Graphs
Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.NBO‐informed molecular graphs represent chemistry via valence orbitals rather than atomic connectivity, enabling consistent reaction analysis across environments. By identifying delocalized motifs and increasing complexity adaptively, the framework enables efficient exploration of inaccessible mechanisms and diverse catalytic and reaction networks for ...
Javier E. Alfonso‐Ramos, Thijs Stuyver
wiley +1 more source
Food Frontiers, Volume 7, Issue 4, July 2026.This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun +6 more
wiley +1 more source