Results 91 to 100 of about 109,495 (390)

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

eLife, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger   +7 more
doaj   +1 more source

Oxidative stress stimulates alpha-tocopherol transfer protein in human trophoblast tumor cells BeWo [PDF]

, 2012
alpha-Tocopherol transfer protein (alpha-TTP) has been identified as the major intracellular transport protein for the antioxidant vitamin E (alpha-Tocopherol).
Etzl, Ronny P., Jeschke, Udo, Kuhn, Christina, Makrigiannakis, Antonis, Poeschl, Johannes M., Rotzoll, Daisy E., Schulze, Sandra, Vrekoussis, Thomas   +7 more
core   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases

International Journal of Molecular Sciences, 2019
Historically, invasion of placental trophoblasts was thought to be extremely specific, only invading into the connective tissues of the maternal uterus and finally reaching and transforming the uterine spiral arteries.
B. Huppertz
semanticscholar   +1 more source

A method for isolating and culturing placental cells from failed early equine pregnancies [PDF]

, 2016
Early pregnancy loss occurs in 6–10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases.
A.J. McGladdery, A.M. de Mestre, Allen, B.V. Rose, C. Smith, Cabrera-Sharp, D.C. Wathes, de Mestre, Diskin, F.E. Barrelet, Greenwold, H. Neal, Hamstead, I.J. Cameron, Inskeep, J. Crowhurst, J. Pynn, J.R. Crabtree, K.L.P. Verheyen, Lanoix, M.J. Firth, O.D. Pynn, Oriol, Petracchi, Raudsepp, Robbin, S. Bate, Seo, Strand, V. Cabrera-Sharp, Vanderwall, Z. Wise   +31 more
core   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Alkaloid leonurine exerts anti‐inflammatory effects via modulating MST1 expression in trophoblast cells

Immunity, Inflammation and Disease, 2021
Background Pre‐eclampsia (PE) is mainly attributed to the inflammation of trophoblast cells in pregnant women, which results in damage to the maternal organs and growth retardation of the fetus.
Fang Zong, Yingzi Zhao
doaj   +1 more source

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao, Zhili Wang, Hyoyong Kim, Hui Kong, Junseok Lee, Jacqueline Ziqian Yang, Anmin Wang, Ryan Y. Zhang, Yong Ju, Jina Kim, Bing Feng, Dejun Liu, Yating Zhang, Zhenfang Wang, Yandong Zhang, Shujing Guo, Dekang Gao, James S. Tomlinson, Renjun Pei, Jipeng Wan, Stephen J. Pandol, Myung‐Shin Sim, Sungyong You, Ding Ma, Shaohua Lu, Na Sun, Hsian‐Rong Tseng, Yazhen Zhu   +27 more
wiley   +1 more source

SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. [PDF]

PLoS Biology, 2008
SUMO-specific protease 2 (SENP2) modifies proteins by removing SUMO from its substrates. Although SUMO-specific proteases are known to reverse sumoylation in many defined systems, their importance in mammalian development and pathogenesis remains largely
Shang-Yi Chiu, Naoya Asai, Frank Costantini, Wei Hsu   +3 more
doaj   +1 more source

Animal models of fetal growth restriction: Considerations for translational medicine. [PDF]

, 2015
Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential. It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause of infant mortality and morbidity.
David, AL, Swanson, AM
core   +1 more source