Results 141 to 150 of about 109,495 (390)

Is intermediate risk really intermediate? Comparison of karyotype and non‐invasive prenatal testing results of pregnancies at intermediate risk of trisomy 21 on maternal serum screening

Journal of Genetic Counseling, Volume 34, Issue 2, April 2025.
Abstract The purpose of this study was to assess the additional contribution of karyotyping compared with genome‐wide non‐invasive prenatal testing (NIPT) for pregnancies at intermediate risk for trisomy 21 (T21), calculated using the maternal serum screening without major structural anomalies detected through sonography.
Gul Alkan Bulbul, Emine Kirtis, Hulya Kandemir, Cem Yasar Sanhal, Sezin Yakut Uzuner, Sibel Berker Karauzum, Ibrahim Inanc Mendilcioglu   +6 more
wiley   +1 more source

β3‐Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta

Medicinal Research Reviews, Volume 45, Issue 3, Page 842-866, May 2025.
ABSTRACT At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia‐inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low‐oxygen environment, including the induction of specific enzymes ...
Luca Filippi, Francesca Innocenti, Francesca Pascarella, Rosa Teresa Scaramuzzo, Riccardo Morganti, Paola Bagnoli, Maurizio Cammalleri, Massimo Dal Monte, Maura Calvani, Alessandro Pini   +9 more
wiley   +1 more source

Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion

Nature Communications, 2019
During pregnancy, trophoblast cells sustain the maternal–fetal tolerance via expressing and secreting various chemokines and cytokines. Our previous study revealed the expression of interleukin-35 (IL-35) in human first-trimester trophoblasts.
Jia Liu, Shengnan Hao, Xi Chen, Hui Zhao, Lutao Du, Hanxiao Ren, Chuanxin Wang, H. Mao   +7 more
semanticscholar   +1 more source

Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells

Stem Cell Research, 2018
During early development in placental mammals, proper trophoblast lineage development is essential for implantation and placentation. Defects in this lineage can cause early pregnancy failures and other pregnancy disorders. However, transcription factors
Bum-Kyu Lee, Nadima Uprety, Yu Jin Jang, Scott K. Tucker, Catherine Rhee, Lucy LeBlanc, Samuel Beck, Jonghwan Kim   +7 more
doaj  

S‐Methyl Methanethiosulfonate, the Main Human Metabolite of S‐Methyl‐L‐Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells

Molecular Nutrition &Food Research, Volume 69, Issue 8, April 2025.
In this study, we show that the sulfur compound commonly found in cruciferous and allium vegetables and the main human metabolite of S‐methyl‐L‐cysteine sulfoxide, called S‐methyl methanethiosulfonate (MMTSO), alters energy metabolism in DU145 prostate cancer cells.
Gemma Beasy, Federico Bernuzzi, Priscilla Day‐Walsh, Perla Tronsco‐Rey, Marianne Defernez, Shikha Saha, Richard F. Mithen, Maria H. Traka, Paul A. Kroon   +8 more
wiley   +1 more source

Vitamin D, the placenta and early pregnancy: effects on trophoblast function.

Journal of Endocrinology, 2018
Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH)2D).
Ankana Ganguly, J. Tamblyn, S. Finn-Sell, Shiao Y Chan, M. Westwood, J. Gupta, M. Kilby, S. Gross, M. Hewison   +8 more
semanticscholar   +1 more source

Interferon-gamma alters the phagocytic activity of the mouse trophoblast

Reproductive Biology and Endocrinology, 2005
Interferon-gamma (IFN-gamma) mediates diverse functions in bone marrow-derived phagocytes, including phagocytosis and microbe destruction. This cytokine has also been detected at implantation sites under both physiological and pathological conditions in ...
Abrahamsohn Ises, Leanza Eduardo C, Gagioti Sonia M, Hoshida Mara S, Albieri Andréa, Croy Anne, Ashkar Ali A, Bevilacqua Estela   +7 more
doaj   +1 more source

ENT‐1‐Targeted Polymersomes to Enhance the Efficacy of Methotrexate in Choriocarcinoma Treatment

Small Science, EarlyView.
ENT‐1‐targeted stimuli‐responsive polymersomes enhance the delivery and release of MTX, as demonstrated in choriocarcinoma tumors mouse model. These targeted nanocarriers improve tumor uptake and efficiently release the drug within the tumor, highlighting their potential for enhanced chemotherapy in choriocarcinoma treatment.
Babak Mamnoon, Ana Paula Mesquita Souza, Tetiana Korzun, Maureen K. Baldwin, K. Shitaljit Sharma, Oleh Taratula, Yoon Tae Goo, Prem Singh, Vladislav Grigoriev, Aryan Lakhanpal, Olena R. Taratula   +10 more
wiley   +1 more source

Regulation of major histocompatibility complex class II gene expression in trophoblast cells

Reproductive Biology and Endocrinology, 2004
Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C, Murphy Shawn P, Holtz Renae   +2 more
doaj   +1 more source

AN ULTRASTRUCTURAL STUDY OF THE REVERSIBILITY OF THE EFFECTS OF HYPOXIA ON HUMAN TROPHOBLAST MAINTAINED IN ORGAN CULTURE [PDF]

, 1975
Alastair H. MacLennan, Matthew J. Carty, B. L. Sheppard, F. Sharp   +3 more
openalex   +1 more source