Uncovering the role of genetic polymorphisms in cervical insufficiency
International Journal of Gynecology &Obstetrics, EarlyView.Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi +3 more
wiley +1 more source
Universality of a mesenchymal transition signature in invasive solid cancers [PDF]
, 2012 In this brief communication, additional computational validation is provided consistent with the unifying hypothesis that a shared biological mechanism of mesenchymal transition, reflected by a precise gene expression signature, may be present in all ...
Dimitris Anastassiou
core +1 more source
The role of DNA methylation in human trophoblast differentiation
Epigenetics, 2018 The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate placental function.
Teena K. J. B. Gamage +9 more
doaj +1 more source
Trophoblasts Protect the Inner Cell Mass from Macrophage Destruction1 [PDF]
, 1993 Ronit Vogt Sionov +3 more
openalex +1 more source
Factors affecting the umbilical artery Doppler reference values in the second and third trimesters
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To explore the contribution of selected methodological factors to the heterogeneity in published umbilical artery pulsatility index (UA‐PI) reference charts. Methods Cross‐sectional study of uncomplicated singleton pregnancies that underwent assessment of UA Doppler at a single center.
Sophia Rahimi +4 more
wiley +1 more source
Early restriction of placental growth results in placental structural and gene expression changes in late gestation independent of fetal hypoxemia [PDF]
, 2016 Placental restriction and insufficiency are associated with altered patterns of placental growth, morphology, substrate transport capacity, growth factor expression, and glucocorticoid exposure.
Barker, P. +6 more
core +1 more source
The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal Interface? [PDF]
, 2008 Human pregnancy poses a fundamental immunological problem because the placenta and fetus are genetically different from the host mother. Classical transplantation theory has not provided a plausible solution to this problem.
Barrier, Breton F. +3 more
core +6 more sources
Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity [PDF]
, 2010 Melissa J. Mulla +6 more
openalex +1 more source
Hematologic markers and machine learning in predicting placenta accreta: A case–control study
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective This study aims to enhance antenatal detection of placenta accreta spectrum (PAS) and predict severe hemorrhage at delivery using machine learning by evaluating the association between antenatal hematologic index trends across trimesters, imaging markers, and patient history.
Michael D. Jochum +11 more
wiley +1 more source
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. [PDF]
, 1996 The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors.
Abrams, JS +5 more
core +1 more source