Results 111 to 120 of about 21,207 (299)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy.

, 2010
The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Staff, A.C., Luft, F.C., Mueller, D.N., Lydia Hering, Brosnihan, KB, Anne C. Staff, Berthold Huppertz, Katrin Wenzel, Wenzel, K., Brosnihan, K.B., Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Wenzel, K, Huppertz, B, Florian Herse, Staff, AC, Ralf Dechend, Nele Geusens, Cartwright, J.E., K. Bridget Brosnihan, Huppertz, B., Geusens, N., Hering, L, Dominik N. Muller, Dechend, R., Hering, L., Verlohren, S, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt‐1 in women with new onset hypertension in pregnancy

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In pregnant women with new‐onset hypertension starting antihypertensives, some achieve tight BP control within a week (Group 1‐blue line), while others respond slower (Group 2‐red line). Group 1 showed higher Log10PLGF levels, but Log10sFlt‐1 did not differ between groups. Over time, Log10PLGF declined in both groups, while Log10sFlt‐1 remained stable.
Edward Tyrell, Katherine G. Y. Lau, Martyna Bednorz, Kypros H. Nicolaides, Nikos A. Kametas   +4 more
wiley   +1 more source

Toll-Like Receptor-3 Ligation-Induced Indoleamine 2, 3-Dioxygenase Expression in Human Trophoblasts

, 2011
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades an essential amino acid, tryptophan, and plays a role in inhibiting the proliferation of T cells and intracellular pathogens.
Kaori Koga, Ingrid Cardenas, Gil Mor, Gentaro Izumi, Masashi Takamura, Bo Wang, Yutaka Osuga, Yasushi Hirota, Miyuki Harada, Osamu Yoshino, Yuji Taketani, Tetsuya Hirata   +11 more
core   +1 more source

Placental basal plate with attached myofibers and adverse pregnancy outcomes: A systematic scoping review

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
The presence of basal plate myometrial fibers was associated with higher rates of placenta‐related pregnancy disorders and abnormal placental attachment in subsequent pregnancies, but heterogeneity in the data was found due to variable inclusion criteria, sampling methods, and reported outcomes.
Eric Jauniaux, Helena C. Bartels, Paul Downey, Francesco D'Antonio   +3 more
wiley   +1 more source

Impaired decidual macrophage efferocytosis of trophoblasts in preeclampsia

Objectives: Preeclampsia (PET) is associated with defective trophoblast invasion, with elevated numbers of apoptotic trophoblasts observed. Decidual macrophages (DMφ) are thought to be key in removal of these cells via efferocytosis, which drives ...
Belchamber, Kylie; id_orcid, Tamblyn, Jennifer   +1 more
core   +1 more source

Clinicopathological phenotypes of singleton stillbirth: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Clinical information, description of placenta, and umbilical cord were reviewed, and microscopic slides re‐evaluated according to the Amsterdam Consensus. Stillbirths with maternal vascular malperfusion often had signs of high‐risk pregnancy, unlike stillbirths with villitis of unknown etiology, fetal vascular malperfusion, and umbilical cord at risk ...
Ragnheidur I. Bjarnadottir, Thora S. Steffensen, Alexander K. Smarason, Karin Pettersson, Nikos Papadogiannakis, Johanna Gunnarsdottir   +5 more
wiley   +1 more source

The role of DNA methylation in human trophoblast differentiation

Epigenetics, 2018
The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate placental function.
Teena K. J. B. Gamage, William Schierding, Daniel Hurley, Peter Tsai, Jackie L. Ludgate, Chandrakanth Bhoothpur, Lawrence W. Chamley, Robert J. Weeks, Erin C. Macaulay, Joanna L. James   +9 more
doaj   +1 more source

Cellular characteristics of canine trophoblasts

This research investigated the development of a novel canine model to study preeclampsia. Normal canine placental development has morphologic and histologic similarities to the shallow trophoblast invasion occurring with preeclampsia in humans, which ...
Sahlfeld, Laura
core  

Establishment of Human Formative Pluripotent Stem Cell‐Like Cells Exhibiting Amniotic Differentiation Potentials

Cell Proliferation, EarlyView.
The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang, Qizhi Wang, Yu Wu, Chen Gu, Mingfei Li, Yong Fan, Xiangjin Kang, Lei Li, Zheng Gao, Mingyan Hei, Jianqiao Liu, Lei Li   +11 more
wiley   +1 more source