Results 141 to 150 of about 18,040 (249)

Erythropoietin Disequilibrium in Hypertensive Disorders of Pregnancy: Molecular Crosstalk, Placental Hypoxia and Perinatal Consequences

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Placental hypoxia, HIF‐1α activation, renal HIF‐2α‐mediated EPO signaling, inflammation, and hepcidin‐driven iron restriction converge to produce functional EPO resistance. This erythropoietin disequilibrium impairs effective erythropoiesis, aggravates maternal vascular dysfunction, compromises placental oxygen transfer, and contributes to adverse ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Altered trophoblasts, macrophages, and immunologic microenvironment in the placenta: Implications of poorly controlled type 2 diabetes mellitus revealed by single-cell transcriptomics. [PDF]

Chin Med J (Engl)
Zhang M, Wang H, Liu Y, Cui D, Ning J, Yan J, Yang H.   +6 more
europepmc   +1 more source

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Cellular determinants of parvovirus B19 susceptibility in the human placenta. [PDF]

PLoS Pathog
Suter C, Küffer M, Bieri J, Fahmi A, Baud D, Alves MP, Ros C.   +6 more
europepmc   +1 more source

The Therapeutic Potential of Stem Cell Therapy for Doxorubicin‐Induced Cardiotoxicity: A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent whose clinical utility is significantly constrained by severe side effects, most notably DOX‐induced cardiotoxicity (DIC). Pathophysiological mechanisms of DIC include oxidative stress, mitochondrial dysfunction, programmed cell death, and inflammation ...
Ali Mirzaei, Pouria Rezaei, Reza Golchin Vafa, Saleheh Jahani, Reza Arefnezhad, Hossein Fatemian, Mohammad Hossein Nikoo, Amirhossein Sahebkar, Fatemeh Rezaei‐Tazangi   +8 more
wiley   +1 more source

Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity. [PDF]

Trends Immunol
Tilburgs T.
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Endothelial Dysfunction in Preeclampsia: Focus on the Uteroplacental Circulation. [PDF]

Arterioscler Thromb Vasc Biol
Tucker SM, Hula N, Gardner JJ, Goulopoulou S.   +3 more
europepmc   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Maternal microRNAs linked to birth deficits due to prenatal alcohol exposure are dominant modifiers of gene expression in invasive trophoblast cells. [PDF]

Front Cell Dev Biol
Upreti D, Chambers CD, Miranda RC.
europepmc   +1 more source