Results 141 to 150 of about 30,805 (282)

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan   +7 more
wiley   +1 more source

Caesarean Scar Ectopic Pregnancy: A Case Study

open access: yesSonography, Volume 13, Issue 2, June 2026.
ABSTRACT Caesarean scar ectopic pregnancy (CSEP) occurs when a blastocyst implants into the residual scar from a previous caesarean section delivery, in the anterior lower uterine segment. In this region the endometrium is thin or absent, and may represent a dehiscence of the mucosal margin of the myometrium, with implantation into the myometrium ...
Tony Parmiter
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, Volume 20, Issue 5, Page 1220-1236, May 2026.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

trophoblast

open access: yes
Citation: 'trophoblast' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11327 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

open access: yesAdvanced Science, Volume 13, Issue 26, 8 May 2026.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He   +18 more
wiley   +1 more source

Sirenomelia: A Review of European Prevalence Data and Epidemiological Analysis of 17 Cases Registered in Wales

open access: yesBirth Defects Research, Volume 118, Issue 5, May 2026.
ABSTRACT Background Sirenomelia is a rare congenital condition most notably characterized by a single lower limb. Previous studies have suggested a prevalence of approximately 1 per 100,000 births. However, in Wales 17 cases were recorded between 1998 and 2016, suggesting a higher rate of sirenomelia in this country.
Chris Emmerson   +30 more
wiley   +1 more source

Expression of MHC II genes

open access: yes, 2005
Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G.   +3 more
core   +2 more sources

A Rare Case of P‐Null Phenotype Identified During Preoperative Screening

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT A 46‐year‐old woman scheduled for an elective total abdominal hysterectomy was incidentally found to have a rare P‐null (p) phenotype during routine preoperative testing. Although her ABO/Rh type was A positive, the antibody screen demonstrated strong pan‐reactivity with all panel cells, while the autocontrol was negative, indicating an ...
Alireza Abdollahi   +3 more
wiley   +1 more source

High‐dimensional multiomics reveals perturbations to IL‐6/IL‐6R axis and RUNX3 in CD4+ T cells during third‐trimester pregnancy

open access: yesClinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives CD4+ T cells play key roles in regulating immune responses during pregnancy; therefore, we aimed to understand the CD4+ T‐cell surface proteome and transcriptome during pregnancy. Methods CD4+ T cells were analysed in blood and decidua from term pregnancies (> 37 weeks) and non‐pregnant blood.
Jennifer R Habel   +17 more
wiley   +1 more source

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