Results 141 to 150 of about 43,593 (324)

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Application of Multimodal Ultrasound Combined With BI‐RADS in Classification and Diagnosis of Non‐Mass Breast Lesions

Journal of Clinical Ultrasound, EarlyView.
This study demonstrates that integrating microvascular flow imaging, shear wave elastography, and contrast‐enhanced ultrasound with the BI‐RADS classification significantly improves the diagnostic accuracy for non‐mass breast lesions, offering a more reliable tool for differentiating benign from malignant findings.
Zengdi Yang, Yongyan Lyu, Yanting Yang, Cuiping Xu, Keke Zhang, Xuxu Yang, Feng Chen, Lanlan Cheng, Minglei Ren   +8 more
wiley   +1 more source

Sonographic Predictors and Long‐Term Reproductive Outcomes in Recurrent Cesarean Scar Pregnancy

Journal of Ultrasound in Medicine, EarlyView.
Objectives To explore the ultrasound findings, treatment strategies, and reproductive outcomes in patients with recurrent cesarean scar pregnancy (CSP), providing evidence for clinical management. Methods We identified 1371 confirmed CSP from 1517 initially screened cases (2012–2022) through blinded image review. From 159 subsequent live births in this
Jianan Shi, Xiaoping Gong, Hui Wang, Tiantian Sun, Guanjie Wang, Ping Chen, Mingtao Xiong   +6 more
wiley   +1 more source

Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia [PDF]

, 2020
Yuhua Ou, Liqiong Zhu, Xiangcai Wei, Shiyu Bai, Manqi Chen, Hui Chen, Jianping Zhang   +6 more
openalex   +1 more source

UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li, Ning Wang, Fan Jiang, Jie‐Cheng Yang, Yan‐Yun Wang, Kun Wang   +5 more
wiley   +1 more source

Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts [PDF]

, 2021
Lindsey N. Block, Jenna Kropp Schmidt, Megan C. McKeon, Brittany D. Bowman, Gregory J. Wiepz, Thaddeus G. Golos   +5 more
openalex   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Localization of Transforming Growth Factor in the Human Placenta and Decidua: Role in Trophoblast Growth1 [PDF]

, 1993
Jeffrey J. Lysiak, Victor K. M. Han, Peeyush K. Lala   +2 more
openalex   +1 more source

Stillbirth in pregnancies with flat OGTT: Placental clues to occult maternal dysmetabolism

International Journal of Gynecology &Obstetrics, EarlyView.
Emma Bertucci, Alessandra Danieli, Francesco Ricciardiello, Isabella Neri, Francesca Monari, Alessandro D. Genazzani, Gaetano Bulfamante, Antonio La Marca, Laura Botticelli, Fabio Facchinetti, Laura Avagliano   +10 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source