Results 191 to 200 of about 21,207 (299)

Hematologic markers and machine learning in predicting placenta accreta: A case–control study

International Journal of Gynecology &Obstetrics, Volume 173, Issue 3, Page 1596-1604, June 2026.
Abstract Objective This study aims to enhance antenatal detection of placenta accreta spectrum (PAS) and predict severe hemorrhage at delivery using machine learning by evaluating the association between antenatal hematologic index trends across trimesters, imaging markers, and patient history.
Michael D. Jochum, Kelly D. Albrecht, Yamely Mendez Martinez, Victoria Zhang, Sanmay Sarada, Brian Burnett, Christina C. Reed, Karin A. Fox, Amir A. Shamshirsaz, Michael A. Belfort, Jessian L. Munoz, Hennie A. Lombaard   +11 more
wiley   +1 more source

Maternal microRNAs linked to birth deficits due to prenatal alcohol exposure are dominant modifiers of gene expression in invasive trophoblast cells. [PDF]

Front Cell Dev Biol
Upreti D, Chambers CD, Miranda RC.
europepmc   +1 more source

Pregnancy Outcomes and Postnatal Health From Transferred Mosaic Embryos Following Preimplantation Genetic Testing for Aneuploidy

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration synthesizes the methods and conclusion of this study, demonstrating that the transfer of mosaic embryos following reimplantation genetic testing for aneuploidy does not increase the risk to postnatal health. ABSTRACT Next‐generation sequencing (NGS) has increased the detection of mosaic embryos during preimplantation genetic testing ...
Lili Chen, Dehuan Huang, Jingcheng Sang, Yiqi Yin, Caiyun Wu, Yan Hao, Dawei Chen, Zhiguo Zhang, Yunxia Cao, Ri‐Cheng Chian, Ping Zhou   +10 more
wiley   +1 more source

Pre-eclampsia-related TLR2/4 signaling activates NOX2/4 to induce oxidative stress and ferroptosis in trophoblasts. [PDF]

Eur J Med Res
Zhang Y, Ke Y, Zhu B, Chen Z, Ren L, Zhang J, Wu J.   +6 more
europepmc   +1 more source

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan, Jiang Jiang, Shuangshuang Tu, Chuanfu Li, Yijun Dong, Yongjin Li, Wenzhi Zhang, Xi Chen   +7 more
wiley   +1 more source

Revised Two-Stage Model of Preeclampsia Based on Autophagic Dysfunction: A Comprehensive Review. [PDF]

Biomolecules
Furuta A, Shima T, Nishigori T, Yamada K, Nunomura H, Yoshida M, Sakaguchi S, Majima T, Yamaki-Ushijima A, Shozu K, Tsuda S, Cheng S, Sharma S, Nakashima A.   +13 more
europepmc   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Hypoxia regulates epithelial to mesenchymal transition-associated genes in human trophoblast cells by modulating DNA methylation. [PDF]

PLoS One
Choudhury J, Dhole B, Aggarwal K, Singh P, Jala MA, Pandey D, Chaturvedi PK, Gupta S.   +7 more
europepmc   +1 more source

Multi‐Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia

MedComm, Volume 7, Issue 6, June 2026.
Preeclampsia, a severe pregnancy‐induced disorder unique to humans, affects ∼5% of pregnancies globally. To understand the pathogenesis of preeclampsia, this study performed a comprehensive multi‐omics analysis of early pregnancy placental biopsies (chorionic villus samples) from pregnancies that later developed preterm/term preeclampsia, compared to ...
Ellen Menkhorst, Guannan Yang, Yimiao Yu, Leilani L. Santos, Wei Zhou, Argyro Syngelaki, Swati Varshney, Nicholas A. Williamson, Kaori Koga, Daniel Lorber Rolnik, Fabricio da Silva Costa, Kypros Nicolaides, Kim‐Anh Lê Cao, Evdokia Dimitriadis   +13 more
wiley   +1 more source

The role of miRNA in modulating oxidative stress in preeclampsia: current knowledge. [PDF]

RNA Biol
Lin C, Xu Q, Yan J, Cao B, Song Y, Tang C.   +5 more
europepmc   +1 more source