Results 181 to 190 of about 21,207 (299)

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

SUMOylation Inhibitor TAK-981 Alleviates Hallmark Features of Preeclampsia Related to High Glucocorticoid Exposure by Inhibiting Placental Oxidative Stress in Rats. [PDF]

Antioxidants (Basel)
Xiao S, Zhang Y, Tang Z, Chen C, Guo D, Long J, Ni X.   +6 more
europepmc   +1 more source

Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how maternal health and nutrition shape gut microbiota via epigenetics to regulate embryonic development. It highlights microbiota‐embryo interactions, disruption by prenatal chemical exposures, and personalized nutrition for disease prevention, offering novel insights and therapeutic targets.
Shoulong Xu, Yanjiao Huang, Chenyue Hu, Wenli Ding, Zhenwei Pu, Qiang Li, Zhiliang Xu   +6 more
wiley   +1 more source

Altered trophoblasts, macrophages, and immunologic microenvironment in the placenta: Implications of poorly controlled type 2 diabetes mellitus revealed by single-cell transcriptomics. [PDF]

Chin Med J (Engl)
Zhang M, Wang H, Liu Y, Cui D, Ning J, Yan J, Yang H.   +6 more
europepmc   +1 more source

MiR‐21‐5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
miR‐21‐5p protects embryonic growth and heart function during developmental hypoxia by dampening HIF responses and shifting gene networks toward improved cardiomyocyte survival and calcium handling. This work identifies miR‐21‐5p as a promising therapeutic target for preventing fetal growth restriction and cardiovascular impairment in high‐risk ...
Bernardo J. Krause, Ximena Calle, Ranya V. Kumar, Youguo Niu, Oriana Ramirez‐Herrera, Damariz Gonzalez, Barbara Bernal, Sage G. Ford, Rachael C. Crew, Anna L. K. Cochrane, German A. Arenas, Alex Di Genova, Dino A. Giussani   +12 more
wiley   +1 more source

Cellular determinants of parvovirus B19 susceptibility in the human placenta. [PDF]

PLoS Pathog
Suter C, Küffer M, Bieri J, Fahmi A, Baud D, Alves MP, Ros C.   +6 more
europepmc   +1 more source

Roles of long non‐coding RNAs in gestational diabetes mellitus: Mechanisms and biomarker potential

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Upregulated lncRNAs in GDM Some key lncRNAs (MALAT1, MEG8, SOX2OT and …) show higher expression in GDM. Downregulated lncRNAs in GDM Some key lncRNAs (HCG27, GASS, Pax AS1 and …) show lower expression in GDM. Mechanistic roles lncRNAs regulate trophoblast proliferation, insulin signalling, neonatal and offspring health and other complications related ...
Reza Kouchaki, Fateme Karimi Dermani, Ishwaree Datta, Sahar Moghbelinejad, Nematollah Gheibi, Farideh Movahed, Fatemeh Samieerad, Saeideh Gholamzadeh Khoei, Hamid Sadeghi   +8 more
wiley   +1 more source

Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity. [PDF]

Trends Immunol
Tilburgs T.
europepmc   +1 more source

Prevalence and Factors Associated With Urologic Injury in Patients With Placenta Accreta Spectrum Undergoing Cesarean Hysterectomy Over a 10‐Year Retrospective Cohort at a Tertiary Referral Center in Shiraz, Iran

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim This study assessed the prevalence, patterns, and risk factors of urologic injuries in patients with placenta accreta spectrum (PAS) undergoing cesarean hysterectomy, aiming to help clinicians identify high‐risk cases and optimize surgical planning.
Shaghayegh Moradi Alamdarloo, Zahra Ovaisi, Hamide Barzegar, Soroush Sadr, Alireza Dehghanmanshadi, Erfan Taherifard, Aazam Faraji, Khadije Bazrafshan, Mohammad Reza Ensafdaran, Atefe Hashemi   +9 more
wiley   +1 more source

Endothelial Dysfunction in Preeclampsia: Focus on the Uteroplacental Circulation. [PDF]

Arterioscler Thromb Vasc Biol
Tucker SM, Hula N, Gardner JJ, Goulopoulou S.   +3 more
europepmc   +1 more source