Results 201 to 210 of about 21,207 (299)

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment. [PDF]

Autophagy
Lu JJ, Sheng YR, Hu WT, Liu YK, Xie F, Li MQ, Zhu XY.   +6 more
europepmc   +1 more source

Caesarean Scar Ectopic Pregnancy: A Case Study

Sonography, Volume 13, Issue 2, June 2026.
ABSTRACT Caesarean scar ectopic pregnancy (CSEP) occurs when a blastocyst implants into the residual scar from a previous caesarean section delivery, in the anterior lower uterine segment. In this region the endometrium is thin or absent, and may represent a dehiscence of the mucosal margin of the myometrium, with implantation into the myometrium ...
Tony Parmiter
wiley   +1 more source

Predictive performance of Fetal Medicine Foundation first‐trimester screening algorithm for pre‐eclampsia according to conception mode

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 806-814, June 2026.
ABSTRACT Objective To investigate the incidence of pre‐eclampsia (PE) and the predictive performance of the Fetal Medicine Foundation (FMF) first‐trimester PE screening algorithm across pregnancies conceived using assisted reproductive technology (ART), after ovulation induction (OI) and through spontaneous conception (SC).
A. S. L. Kjaer, I. Riishede, L. Rode, R. B. Jensen, K. Pihl, L. Sperling, M. Overgaard, N. G. Pedersen, A. C. Roslev, P. Sandager, A. Tabor, A. Pinborg, C. K. Ekelund, the PRESIDE Study Group, P. Nørgaard, C. Vedel, H. Skov, S. R. Wagner, H. J. Zingenberg, M. R. Andersen, L. Bathum, T. Hilling, C. S. Knudsen, F. S. Jørgensen   +23 more
wiley   +1 more source

Lifestyle Intervention During Pregnancy Is Associated With Favourable Changes of Vitronectin in Women With Obesity: Results From the Randomised LiP Trial

Clinical Obesity, Volume 16, Issue 3, June 2026.
ABSTRACT Obesity in pregnancy is a well‐established risk factor for adverse maternal and neonatal outcomes, including gestational diabetes mellitus (GDM). This study aimed to examine the effects of lifestyle intervention during pregnancy on the cardio‐metabolic protein profile and its association with maternal and neonatal health.
Birgitte Moeller Luef, Katrine Sølling Borlund Mortensen, Lasse Møllegaard Obel, Louise Laage Stentebjerg, Per Glud Ovesen, Patrick M. Catalano, Jan Stener Jørgensen, Dorte Møller Jensen, Christina Anne Vinter, Martin Overgaard   +9 more
wiley   +1 more source

Exosomal circDNAJB6 derived from decidual macrophages promotes preeclampsia progression via the miR-670-5p/TOB2 axis and by subsequently regulating the PPARγ/NF-κB pathway. [PDF]

J Transl Med
Zhang L, Tian X, Liu M, Zong H, Yu W, Zheng C, Zhang D, Zhang H.   +7 more
europepmc   +1 more source

Challenges in Implementing Revocation of Oncology Drugs Under Conditional Early Approval in Japan: Regulatory Insights From Comparisons With FDA/EMA

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Expedited pathways in the United States (U.S.), European Union (EU), and Japan (JP) enable earlier access to innovative therapies for rare and serious diseases. In 2025, Japan explicitly introduced revocation provisions to its Conditional Early Approval (CEA).
Takahiro Handa, Arata Tanaka, Mayumi Shikano, Rika Wakao   +3 more
wiley   +1 more source

Beyond traditional models: microfluidic technologies for engineering the human placenta <i>in vitro</i>. [PDF]

Front Bioeng Biotechnol
Masserdotti A, Cargnoni A, Ramakrishnan R, Muiznieks L, Lereculey-Beaumanoir J, Brenta I, Gasik M, Chiodelli P, Silini AR, Parolini O.   +9 more
europepmc   +1 more source

Comprehensive Genomic Characterization Between Urothelial Carcinoma Subtypes/Divergent Differentiation (S/DD) and Pure Urothelial Carcinoma Using a Large‐Scale Japanese Genomic Panel Dataset

International Journal of Urology, Volume 33, Issue 6, June 2026.
ABSTRACT Objectives Urothelial carcinoma (UC) is a common malignancy; however, UC subtypes/divergent differentiation (S/DD) accounts for only 10%–20% of overall cases. S/DD's aggressive biological behavior significantly affects its prognosis and therapeutic decision‐making; thus, elucidating its genomic landscape within UC is important.
Go Kobayashi, Yohei Sekino, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Testutaro Hayashi, Kazuhiro Sentani, Nobuyuki Hinata   +10 more
wiley   +1 more source