Stochastic simulations of self-organized elastogenesis in the developing lung. [PDF]
PLoS Computational Biology, 2023 In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with
Xiru Fan +5 more
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Evolutionary constraints on positional sequence, collective properties and sequence style of tropoelastin dictated by fundamental requirements for formation and function of the extracellular elastic matrix [PDF]
Matrix Biology PlusElastin is the extracellular matrix protein responsible for properties of extension and energy-efficient elastic recoil in large blood vessels, lung parenchyma and other vertebrate tissues.
Fred W. Keeley
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The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging [PDF]
Advanced ScienceCellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular
Sunny Shinchen Lee +4 more
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Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly [PDF]
Redox ReportBackground Tropoelastin (TE), the soluble precursor of elastin, is critical for the elasticity of arteries, lungs, and skin. Oxidative damage to TE has been implicated in vascular diseases, but the isoform-specific effects remain poorly understood ...
Karoline Lindgaard Mikkelsen +3 more
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Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells [PDF]
Nature CommunicationsMicrofibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny +6 more
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Tropoelastin Promotes the Formation of Dense, Interconnected Endothelial Networks
Biomolecules, 2021 Tropoelastin, the soluble precursor of elastin, has been used for regenerative and wound healing purposes and noted for its ability to accelerate wound repair by enhancing vascularization at the site of implantation.
Aleen Al Halawani +3 more
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Fibrous Scaffolds From Elastin-Based Materials
Frontiers in Bioengineering and Biotechnology, 2021 Current cutting-edge strategies in biomaterials science are focused on mimicking the design of natural systems which, over millions of years, have evolved to exhibit extraordinary properties. Based on this premise, one of the most challenging tasks is to
Jose Carlos Rodriguez-Cabello +9 more
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Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix. [PDF]
PLoS ONE, 2017 Smooth muscle cells contribute to extracellular matrix remodeling during atherogenesis. De-differentiated, synthetic smooth muscle cells are involved in processes of migration, proliferation and changes in expression of extracellular matrix components ...
Stephanie E Seidl +6 more
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Frontiers in Materials, 2021 Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants.
Lubinda Mbundi +5 more
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Journal of Functional Biomaterials, 2023 Mesenchymal stem cells (MSCs) have recently been widely used to treat osteoarthritis (OA). Our prior research shows that tropoelastin (TE) increases MSC activity and protects knee cartilage from OA-related degradation.
Shuo Meng +8 more
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