The cross-linking of elastin by lysyl oxidase (LOX) family members is essential for the integrity and elasticity of elastic fibers, which play an important role in the characteristic resilience of various tissues. However, the temporal sequence of oxidation by LOX during elastic fiber formation is still incompletely understood.
Hiroyasu Sakai+5 more
openaire +4 more sources
Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent
This paper summarizes the latest applications and potential mechanisms of the rare earth element gadolinium in biomedical fields, in addition to its traditional application as an MRI contrast agent, including osteogenesis, antimicrobial, antitumor, bioimaging, bioprobes, and so on.
Xingtong Pan+9 more
wiley +1 more source
Blockage of tropoelastin secretion by monensin represses tropoelastin synthesis at a pretranslational level in rat smooth muscle cells. [PDF]
The blockage of protein secretion in the R22 cultured rat aortic smooth muscle cell strain with monensin repressed tropoelastin gene expression at the mRNA level by ca. 50-fold as measured by biosynthetic pulse-labeling, in vitro translation, and hybridization with a tropoelastin genomic DNA probe.
Zena Werb+2 more
openaire +3 more sources
Magnetically responsive tropoelastin hydrogel as a platform for soft tissue regeneration applications [PDF]
Publicado em "European Cells and Materials. ISSN 1473-2262. Vol. 33, Suppl. 2, 2017 (0006)"The natural polymer tropoelastin is a structural protein of ECM of tissues requiring elasticity as part of their function, including ligaments and tendons ...
Almeida, Raquel Costa+5 more
core
Effects of Infrared Radiation and Heat on Human Skin Aging in vivo [PDF]
Sunlight damages human skin, resulting in a wrinkled appearance. Since natural sunlight is polychromatic, its ultimate effects on the human skin are the result of not only the action of each wavelength separately, but also interactions among the many ...
Cho, Soyun+6 more
core +1 more source
Although a morphologically distinct population of lipid-laden interstitial cells (lipofibroblasts, LF), has been identified, the origins and functions of this population during lung development and disease remain undefined.
Heshun Chen+3 more
doaj
An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation. [PDF]
BACKGROUND:Spinal cord injuries (SCI) can lead to severe bladder pathologies associated with inflammation, fibrosis, and increased susceptibility to urinary tract infections. We sought to characterize the complex pathways of remodeling, inflammation, and
Silvia Wognum+4 more
doaj +1 more source
Phase behavior and chain dynamics of elastin-like peptides versus amino acid sequences [PDF]
Elastin fibrillogenesis is conditioned by multiple self-assembly processes. Previous studies have evidenced the crucial influence of amino acid specificities on molecular organization of glycine-rich elastin-like peptides, but also the important role of ...
Bochicchio, Brigida+4 more
core +2 more sources
This study explores the interplay between self‐assembly and di‐tyrosine bond formation in silk fibroin hydrogels photo‐crosslinked with ruthenium and sodium persulfate. The resultant dual crosslinked network is dynamic and changes over time, with hydrogel morphology, mechanical properties, and opacity tailorable via silk concentration, molecular weight,
Hien A. Tran+15 more
wiley +1 more source
Influence of the architecture on the molecular mobility of synthetic fragments inspired from human tropoelastin [PDF]
This work deals with the vibrational, thermal and dielectric characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin. This peptide was shown to form amyloid-like fibers implied in neurodegenerative pathologies.
Bochicchio, Brigida+5 more
core +2 more sources